Results 151 to 160 of about 3,158,693 (427)

Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non‐small‐cell lung cancer characterizes the features of response to PD‐1 blockade plus chemotherapy

Cancer Communications, Volume 42, Issue 12, Page 1331-1346, December 2022., 2022
Abstract Background Although programmed cell death 1 (PD‐1) blockade plus chemotherapy can significantly prolong the progression‐free survival (PFS) and overall survival (OS) in first‐line settings in patients with driver‐negative advanced non‐small‐cell lung cancer (NSCLC), the predictive biomarkers remain undetermined.
Fengying Wu, Tao Jiang, Gongyan Chen, Yunchao Huang, Jianying Zhou, Lizhu Lin, Jifeng Feng, Zhehai Wang, Yongqian Shu, Jianhua Shi, Yi Hu, Qiming Wang, Ying Cheng, Jianhua Chen, Xiaoyan Lin, Yongsheng Wang, Jianan Huang, Jiuwei Cui, Lejie Cao, Yunpeng Liu, Yiping Zhang, Yueyin Pan, Jun Zhao, LiPing Wang, Jianhua Chang, Qun Chen, Xiubao Ren, Wei Zhang, Yun Fan, Zhiyong He, Jian Fang, Kangsheng Gu, Xiaorong Dong, Tao Zhang, Wei Shi, Jianjun Zou, Xuejuan Bai, Shengxiang Ren, Caicun Zhou, the CameL Study Group   +39 more
wiley   +1 more source

Comparing open and minimally invasive surgical procedures for oesophagectomy in the treatment of cancer: the ROMIO (Randomised Oesophagectomy: Minimally Invasive or Open) feasibility study and pilot trial [PDF]

, 2015
Localised oesophageal cancer can be curatively treated with surgery (oesophagectomy) but the procedure is complex with a risk of complications, negative effects on quality of life and a recovery period of 6-9 months. Minimal-access surgery may accelerate
Avery, K, Barham, P, Berrisford, R, Blazeby, JM, Donovan, JL, Elliott, J, Falk, S, Fernandez, AM, Goldin, R, Hanna, G, Hollowood, A, Metcalfe, C, Noble, SM, Sanders, G, Streets, C, Titcomb, D, Wheatley, T   +16 more
core   +1 more source

Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions

Advanced Science, EarlyView.
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian   +11 more
wiley   +1 more source

Sintilimab versus docetaxel as second‐line treatment in advanced or metastatic squamous non‐small‐cell lung cancer: an open‐label, randomized controlled phase 3 trial (ORIENT‐3)

Cancer Communications, Volume 42, Issue 12, Page 1314-1330, December 2022., 2022
Abstract Background Treatment options for Chinese patients with locally advanced or metastatic squamous‐cell non‐small‐cell lung cancer (sqNSCLC) after failure of first‐line chemotherapy are limited. This study (ORIENT‐3) aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second‐line treatment in patients with locally advanced ...
Yuankai Shi, Lin Wu, Xinmin Yu, Puyuan Xing, Yan Wang, Jianying Zhou, Airong Wang, Jianhua Shi, Yi Hu, Ziping Wang, Guangyu An, Yong Fang, Sanyuan Sun, Caicun Zhou, Changli Wang, Feng Ye, Xingya Li, Junye Wang, Mengzhao Wang, Yunpeng Liu, Yanqiu Zhao, Ying Yuan, Jifeng Feng, Zhendong Chen, Jindong Shi, Tao Sun, Gang Wu, Yongqian Shu, Qisen Guo, Yi Zhang, Yong Song, Shucai Zhang, Yuan Chen, Wei Li, Hongrui Niu, Wenwei Hu, Lijun Wang, Jianan Huang, Yang Zhang, Ying Cheng, Zhengdong Wu, Bo Peng, Jiya Sun, Christoph Mancao, Yanqi Wang, Luyao Sun   +45 more
wiley   +1 more source

Cardiothoracic surgery in the midst of a pandemic: Operative outcomes and maintaining a coronavirus disease 2019 (COVID-19)–free environmentCentral MessagePerspective

JTCVS Open, 2020
Objective: In the United Kingdom, the coronavirus disease 2019 (COVID-19) pandemic has led to the cessation of elective surgery. However, there remains a need to provide urgent and emergency cardiac and thoracic surgery as well as to continue time ...
Damian Balmforth, FRCS(CTh), PhD, Martin T. Yates, MBBS, MD, Kelvin Lau, FRCS (CTh), PhD, Azhar Hussain, MBBS, Ana Lopez-Marco, FRCS (CTh), PhD, Stephen Edmondson, FRCS, (CTh), Aung Oo, FRCS (CTh), PhD, Rakesh Uppal, FRCS (CTh), A. Sepehripour, K. Lall, N. Roberts, C. Di Salvo, S. Kolvekar, K. Wong, S. Ambekar, A. Sheikh, B. Adams, J. Yap, D. Lawrence, W. Awad, A. Shipolini, C. Rathwell, Mohamed Rahnavardi, Steven Stamenkovic, David Waller, Henrietta Wilson, May Al-Sahaf   +26 more
doaj  

Pattern and Outcome of Chest Injuries at Bugando Medical Centre in Northwestern Tanzania. [PDF]

, 2011
Chest injuries constitute a continuing challenge to the trauma or general surgeon practicing in developing countries. This study was conducted to outline the etiological spectrum, injury patterns and short term outcome of these injuries in our setting ...
A Kalliopi, A Kuzuku, AA Adem, C Cooper, C Raul, CJ Aylwin, D Wisner, DL Miller, E Blasco, EQ Archampong, F William, FA Massaga, G Chalkiadakis, G Ozgen, I Inci, I Inci, I Inci, Joseph B Mabula, JS Bender, K Frimpong-Boateng, K Park, KN Kimberly, LG Grover, LM Museru, M Atri, M Bishop, Monafisha K Lema, N Ali, OF Grimes, P Catoire, Phillipo L Chalya, R Lambrecth, RM Shorr, S Avakan, S Taché, SA Dulchavsky, T Gizaw, T Otieno, WH Harrison, William Mahalu   +39 more
core   +2 more sources

Using Lean Six Sigma to improve rates of day of surgery admission in a national thoracic surgery department

International Journal for Quality in Health Care, 2019
Objective The aim of this study is to improve rates of day of surgery admission (DOSA) for all suitable elective thoracic surgery patients. Design Lean Six Sigma (LSS) methods were used to enable improvements to both the operational process and the ...
Rachel Brown, P. Grehan, M. Brennan, D. Carter, Aoife Brady, Eoin Moore, S. P. Teeling, M. Ward, D. Eaton   +8 more
semanticscholar   +1 more source

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

Advanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao, Siwen Chen, Hua Chao, Zihao Li, Hao Yang, Dongying Chen, Sifang Li, Shuai Zhang, Jingyu Zhang, Jianru Wang, Zemin Li, Xiang Li, Zhongping Zhan, Tangming Guan, Yiwen Zhang, Wende Li, Hui Liu   +16 more
wiley   +1 more source

A systematic review of infected descending thoracic aortic grafts and endografts

, 2019
Objective: The objective of this study was to collect and critically analyze the current evidence on the modalities and results of treatment of descending thoracic aortic surgical graft (SG) and endograft (EG) infection, which represents a rare but ...
Chakfe, Nabil, Chiesa, Roberto, Grandi, Alessandro, Kahlberg, Andrea, Loschi, Diletta, Melissano, Germano, Moreels, Nathalie, Vermassen, Frank   +7 more
core   +1 more source

Transfusion of red blood cells: the impact on short-term and long-term survival after coronary artery bypass grafting, a ten-year follow-up. [PDF]

, 2010
Transfusion of red blood cells (RBC) and other blood products in patients undergoing coronary artery bypass grafting (CABG) is associated with increased mortality and morbidity.
Bekker, Margreet, De Wolf, Andreas, Hamad, Mohamed, Martens, Elisabeth, Schönberger, Jacques, van Straten, Albert, Van Zundert, Adrien   +6 more
core   +1 more source