Results 81 to 90 of about 408,833 (313)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Rudolf Nissen's years in bosphorus and the pioneers of thoracic surgery in Turkey

, 2000
Rudolph Nissen is one of the most distinguished pioneers in thoracic surgery, well known for his pneumonectomy operation performed for the first time in surgical history.
BATIREL, HASAN FEVZİ
core   +2 more sources

Awake thoracic surgery: a historical perspective

, 2012
During the early twentieth century, thoracic surgery procedures were frequently attempted through local anesthesia, although the pneumothorax created after opening of the chest wall was deemed invariably fatal.
MINEO, TOMMASO CLAUDIO, Mineo, TC, Pompeo, E, POMPEO, EUGENIO   +3 more
core   +1 more source

STS 2019 Workforce Report: Ad Hoc Analysis of Women in Cardiothoracic Surgery

, 2021
The Society of Thoracic Surgeons (STS) is the world’s largest cardiothoracic surgical organization, representing more than 7500 surgeons, researchers, and allied health care professionals worldwide. In response to the ever-changing working environment of
Boden, Natalie, Donington, Jessica S., Ceppa, DuyKhanh P., Ikonomidis, John S., Timsina, Lava R., Kane, Lauren C.   +5 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Quality of life in survivors of thoracic aortic surgery

, 1999
BACKGROUND: The results of surgical repair of thoracic aortic lesions are improving. Still, mortality and morbidity are considerable. Outcomes need to be studied in greater detail. We studied quality of life in survivors of thoracic aortic surgery, which
Olsson, Christian,, Thelin, Stefan,
core   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Selective lobar collapse for video-assisted thoracic surgery

, 2004
Background. Video-assisted thoracic surgery (VATS) is conventionally performed under single-lung ventilation. A small proportion of patients are often excluded from undergoing VATS because of their inability to tolerate single-lung ventilation.
Ho, KM, Yim, APC, Lee, TW, Sihoe, ADL, Sze, TS   +4 more
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Understanding our thoracic surgery workforce: Who, what, and where we practiceCentral MessagePerspective

JTCVS Open
Objective: The makeup of the thoracic surgical workforce can influence policy, training, and certification, but it is not well defined. Using data from the American Board of Thoracic Surgery, this study explored practice-based demographics concerning ...
Jacob Daniel, Malcolm DeCamp, MD, Jennifer Romano, MD, Betty Tong, MD, Michael Moulton, MD, John Mitchell, MD, Carl Backer, MD, Joseph Cleveland, MD, David T. Cooke, MD, Raphael Kella, DO, Joseph Coselli, MD, Jessica Donington, MD, Stephanie Fuller, MD, Adil Husain, MD, Chris Malaisrie, MD, Sandra Starnes, MD, John Stulak, MD, Cameron Wright, MD, Michael Mack, MD, Tom C. Nguyen, MD   +19 more
doaj   +1 more source