Results 121 to 130 of about 90,447 (255)

Obesity Disrupts H3K4me3‐Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Obesity disrupts macrophage adaptation to hypoxic microenvironments. In lean conditions, hypoxia induces H3K4me3‐dependent transcriptional programs that promote lactate accumulation, histone lactylation, and efficient efferocytosis. Diet‐induced obesity impairs this epigenetic–metabolic response, resulting in reduced lactate accumulation, defective ...
Kentaro Takahashi, Julia Drolet, Jinghua Liu, Jasmine R. Jackson, Madison Babcock, Muthusamy Thiruppathi, Milie Fang, Tyler Paul, Gayathri Ganesh, Yuri Fukasawa, Yoshikiyo Akasaka, Giamila Fantuzzi, Elizaveta V. Benevolenskaya, Timothy J. Koh, Norifumi Urao   +14 more
wiley   +1 more source

Minimally Invasive Thoracoscopic Resection of a Giant Right‐Atrial Lipoma on the Beating Heart: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Primary cardiac lipomas are rare benign tumors that are usually indolent but may cause compression or arrhythmia when large. We sought to describe the safety and feasibility of a totally thoracoscopic, off‐pump approach for their resection. A 33‐year‐old asymptomatic woman was found to have a 5.1 × 3.6 cm fat‐density mass at the roof of the ...
Liang Zhou, Yichao Wang, Fan Yang, Haitao Liu   +3 more
wiley   +1 more source

A case report of colon interposition radical surgery performed via unilateral thoracotomy in a patient with esophageal cancer after billroth II gastrectomy

Frontiers in Oncology
IntroductionWhen a gastric tube cannot be used as a substitute for the esophagus, the colon offers several advantageous features for esophageal replacement. However, this procedure remains complex and necessitates patients to have a favorable nutritional
Chun-Guang Wang, Guang-Xin Zhang, Yan Zhang, Hang Guo, Guang-Lei Zhang, Zhen-Hua Kang   +5 more
doaj   +1 more source

Letter Regarding "Repeated Intercostal Nerve Blocks With Liposomal Bupivacaine for Chronic Chest Pain: A Case Report". [PDF]

, 2020
Finneran, John J, Ilfeld, Brian M
core   +1 more source

Recollections of My Research in Developing the Heart-Lung Machine at Jefferson Medical College [PDF]

, 2005
A personal memoir written by Dr. Bernard J. Miller about his introduction to and interest in medical research as well as his experiences working on the heart-lung machine. He focuses specifically on his working relationship with John H.
Miller, Bernard J.
core   +1 more source

Inhaled 5‐HT1B/1D Receptor Antagonist Attenuates Sumatriptan‐Induced Sensitization of Capsaicin‐Sensitive Lung Vagal Afferents: Implications for Preventing Sumatriptan‐Associated Adverse Chest Symptoms

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Our previous study suggests that sumatriptan‐induced chest discomfort is associated with hypersensitivity of CSLV afferents via 5‐HT1B/1D receptors on nerve endings. The present study demonstrates that inhaled 5‐HT1B/1D receptor antagonism suppresses this hypersensitivity without compromising antimigraine efficacy, supporting local pulmonary antagonism
Nai‐Ju Chan, Zung Fan Yuan, Chang‐Chih Kuo, Chun‐Chun Hsu   +3 more
wiley   +1 more source

Complications of Tuberculosis: A Case Study on Bronchopleural Fistula and Failed Conservative Management

Annals of Medicine and Medical Sciences
Bronchopleural fistula (BPF) is a severe complication of pulmonary tuberculosis, particularly prevalent in high TB incidence regions like Indonesia.
Noni Novisari Soeroso, Aida Aida, Setia Putra Tarigan, Andika Pradana, Brema Suranta Pasaribu, Halina Julia   +5 more
doaj  

Protective Mechanism of Aqueous Extract From Ixeris sonchifolia in Myocardial Ischemia–Reperfusion Injury: Insights From Network Pharmacology and Experimental Validation

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study evaluated KDZ aqueous extract's therapeutic potential for MI/RI and investigated its mechanism. In a mouse MI/RI model, the aqueous extract mitigated injury and preserved cardiac function. Liquid chromatography‐mass spectrometry (LC–MS) identified eighty‐six components. Based on Compound‐target‐disease interaction network and KEGG enrichment
Xiaoxia Tian, Baoyi Chen, Longtai Chen, Kuan Liu, Jiazhao Chu, Fang Liu, Sijing Feng, Lina Lai   +7 more
wiley   +1 more source

Fetal Cardiac Extracellular Matrix Incorporated Into Silk Scaffolds Leads to Beneficial Cardiovascular Patch Remodeling in a Large Animal Model of RVOT Surgical Repair

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 4, April 2026.
ABSTRACT Approximately 50% of patients that undergo surgical reconstruction to repair the congenital heart defect tetralogy of Fallot (ToF) experience adverse effects by the age of 50. These effects can be linked to the poor healing response elicited by the synthetic materials in the commonly used cardiovascular patches.
Elizabeth C. Porter, Yan‐Ru Lai, Whitney L. Stoppel, Luke R. Perreault, David L. Kaplan, Raymond K. Kudej, Lauren D. Black III   +6 more
wiley   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source