Results 51 to 60 of about 113,271 (369)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The unusual role of surface recrystallization on creep damage behavior of GH3535 alloy weld metal

Journal of Materials Research and Technology
It is generally believed that surface recrystallization is detrimental to the mechanical properties of superalloys. However, in our study, surface recrystallization exerts a double-edged effect on the creep damage behavior of GH3535 alloy weld metal at ...
Hanigeer Sun, Li Jiang, Xiao-Yan Wang, Zhijun Li   +3 more
doaj   +1 more source

Preclinical Efficacy of a PSMA-Targeted Thorium-227 Conjugate (PSMA-TTC), a Targeted Alpha Therapy for Prostate Cancer

Clinical Cancer Research, 2019
Purpose: Prostate-specific membrane antigen (PSMA) is an attractive target for radionuclide therapy of metastatic castration-resistant prostate cancer (mCRPC).
S. Hammer, U. Hagemann, S. Zitzmann-Kolbe, Aasmund Larsen, Christine Ellingsen, Solène Géraudie, D. Grant, Baard Indrevoll, R. Smeets, O. von Ahsen, A. Kristian, P. Lejeune, H. Hennekes, J. Karlsson, R. Bjerke, O. B. Ryan, A. Cuthbertson, D. Mumberg   +17 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Octant overlapping and angle-energy group expanded KBA parallelism of three-dimensional discrete ordinate method

Frontiers in Energy Research
IntroductionTo enhance the parallel efficiency of the conventional KBA spatial decomposition method, this study incorporates octant overlapping and angle-energy group expansion into the source iteration scheme for solving the discrete ordinate equations ...
Jian Guo, Jian Guo, Yang Zou, Yang Zou, Xuechao Zhao, Xuechao Zhao, Rui Yan, Rui Yan   +7 more
doaj   +1 more source

Coupled Analysis of Thorium-based Fuels in the High-Performance Light Water Reactor Fuel Assembly

Atom Indonesia, 2021
One of the six selected concepts to be part of Generation IV nuclear reactors is the Supercritical Light Water Cooled Reactor. The High-Performance Light Water Reactor (HPLWR) is the European version and it is a very promising design.
Y. Pérez, C. R. García, F. L. Mena, L. Castro   +3 more
doaj   +1 more source

Performance of a 229 Thorium solid-state nuclear clock

, 2012
The 7.8 eV nuclear isomer transition in 229 Thorium has been suggested as an etalon transition in a new type of optical frequency standard. Here we discuss the construction of a "solid-state nuclear clock" from Thorium nuclei implanted into single ...
A N Litvinov, A V Romanenko, Beck B R Wu C Y Beiersdorfer P Brown G V Becker J A Moody K J Wilhelmy J B Porter F S Kilbourne C A Kelley R L, Bemis C E, G A Kazakov, G Winkler, Jackson R, Kazakov G A Schreitl M Winkler G Sterba J H Steinhauser G Schumm T, L P Yatsenko, M Schreitl, Mohn P, Parker T E, Peik E, Peik E Zimmermann K Okhapkin M Tamm Ch, Quessada A, Riehle F, T Schumm, V I Romanenko, Vanier J   +18 more
core   +1 more source

Resonance ionization spectroscopy of thorium isotopes - towards a laser spectroscopic identification of the low-lying 7.6 eV isomer of Th-229 [PDF]

, 2011
In-source resonance ionization spectroscopy was used to identify an efficient and selective three step excitation/ionization scheme of thorium, suitable for titanium:sapphire (Ti:sa) lasers.
Blaise J, I D Moore, Izosimov I, K Wendt, Kurucz R L, Kälber W, M Reponen, Moore I, N Trautmann, Peik E, S Raeder, S Rothe, T Gottwald, Tkalya E V, V Sonnenschein, Vernyi E A   +15 more
core   +3 more sources

Mesothelin-Targeted Thorium-227 Conjugate (MSLN-TTC): Preclinical Evaluation of a New Targeted Alpha Therapy for Mesothelin-Positive Cancers

Clinical Cancer Research, 2019
Purpose: Targeted thorium-227 conjugates (TTC) represent a new class of molecules for targeted alpha therapy (TAT). Covalent attachment of a 3,2-HOPO chelator to an antibody enables specific complexation and delivery of the alpha particle emitter thorium-
U. Hagemann, Christine Ellingsen, J. Schuhmacher, A. Kristian, Anne Mobergslien, V. Cruciani, Katrine Wickstroem, Christoph A Schatz, C. Kneip, S. Golfier, R. Smeets, S. Uran, H. Hennekes, J. Karlsson, R. Bjerke, O. B. Ryan, D. Mumberg, K. Ziegelbauer, A. Cuthbertson   +18 more
semanticscholar   +1 more source

Date seed as an efficient, eco-friendly, and cost-effective bio-adsorbent for removal of thorium ions from acidic solutions

, 2020
Removal of thorium ions from acidic media using high effective bio-adsorbent is a very convenient viewpoint for the management of environmental pollutants. With this respect, this study is aimed to synthesize bio-adsorbent derived from date palm seed (DS
A. Sayed, M. Abdelmottaleb, M. Cheira, Gamal Abdel-aziz, H. Gomaa, T. Hassanein   +5 more
semanticscholar   +1 more source