Results 91 to 100 of about 2,866,898 (311)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Contemporary Social Sciences, 2017 Over 70 percent of China’s remaining impoverished people live in rural areas in the western region. With constraints such as relatively adverse natural conditions and extreme decentralization as well as a rapid decrease of marginal benefit of the ...
Zhang Jianjun
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Why Teach History of Economic Thought Today? [PDF]
Shorter undergraduate studies, increasing specialization and the priority of applied research in Economics represent threats for the History of Economic Thought (HET) as an integral part of the training of young economists.
Andrés Álvarez, Jimena Hurtado
core
, 2013 Dois músicos sociólogos se fizeram a seguinte pergunta: como quatro caras que nunca se encontraram e que não têm nenhuma música escrita, apertam as mãos, e começam a tocar de uma forma que parece que eles estão trabalhando juntos há anos? Faulkner e Becker decidiram responder a pergunta com pesquisa de campo.
Becker, Howard S., Falkner, Robert R.
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Novìtnâ Osvìta, 2015 The article is aimed at the problem of language-thought interrelation which has always been of great interest to philosophers and linguists as the former is inconceivable without the latter; thus, language and thought are inseparable.
I. O. Gaidenko
doaj +1 more source
Journal of Graduate Medical Education, 2016 T he dreaded sheath pull, bane of every interventional fellow’s existence. A maligned but critical necessity, it inevitably engenders a visceral sense of discontent amplified by the fact that nurses are unhappy because it disrupts their workflow and patients are certainly not pleased at the prospect of another 4 to 6 hours of recumbence, having already
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source