Results 71 to 80 of about 7,701,068 (306)
Language as an instrument of thought [PDF]
, 2016 I show that there are good arguments and evidence to boot that support the language as an instrument of thought hypothesis. The underlying mechanisms of language, comprising of expressions structured hierarchically and recursively, provide a perspective (
Akmajian +117 more
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
, 1999 Excerpt: A behavioral technique used to help persons troubled by recurring uncontrolled thoughts and worries. Examples include obsessive rumination about cleanliness that persists even after careful washing, excessive fear of riding in automobiles or ...
Bufford, Rodger K.
core
American Philosophical Quarterly, 2017 Abstract According to a criterion of difference for thoughts derived from Frege, two thoughts are different if it is at the same time possible for a rational subject to take conflicting epistemic attitudes toward them. But applying this criterion to perception-based demonstrative thoughts seems to slice thoughts too finely and lead to ...
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Contending Visions of Contemporary Islamic Reassertion
Journal of Islamic Thought and Civilization, 2018 The understanding of contemporary Islamic activism has become one of the most important challenges for international academia since the 1980s. Late 1970s and early 1980s, witnessed a chain of unexpected but significant happenings in the heart of the ...
Mian Muhammad Rafi, Humaira Ahmad
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2016 Purpose. The purpose of research consists in that: having plunged into depths of primitive consciousness (using the recipe of many thinkers of non-classical philosophy), to reveal contradiction of the European thought (at its sources) in Ancient Greek ...
V. B. Okorokov
doaj +1 more source