Results 71 to 80 of about 2,120,226 (267)
Contemporary Social Sciences, 2017 Over 70 percent of China’s remaining impoverished people live in rural areas in the western region. With constraints such as relatively adverse natural conditions and extreme decentralization as well as a rapid decrease of marginal benefit of the ...
Zhang Jianjun
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Future of Islamic Civilization, Emerging Issues and New Horizons
Journal of Islamic Thought and Civilization, 2019 This paper investigates four dimensions of Islamic Movements in Malaysian context. The first one is about the impacts of Islamic Movements instigating the development of Islamic civilization in Malaysia.
Sajid Iqbal Sheikh +1 more
doaj
Novìtnâ Osvìta, 2015 The article is aimed at the problem of language-thought interrelation which has always been of great interest to philosophers and linguists as the former is inconceivable without the latter; thus, language and thought are inseparable.
I. O. Gaidenko
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Interactivity and thought [PDF]
, 2011 A shared tenet of embodied, embedded, situated and distributed cognition is that people make sense of things interactively. They run a simulation, they exchange words, often taking turns to change and steer the flow of interaction; they gesture, they handle or manipulate things, they write, sketch or model.
Kirsh, David +3 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Journal of Graduate Medical Education, 2016 T he dreaded sheath pull, bane of every interventional fellow’s existence. A maligned but critical necessity, it inevitably engenders a visceral sense of discontent amplified by the fact that nurses are unhappy because it disrupts their workflow and patients are certainly not pleased at the prospect of another 4 to 6 hours of recumbence, having already
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source