Results 61 to 70 of about 7,701,068 (306)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Realisation of Hardy's Thought Experiment
, 2004 We present an experimental realisation of Hardy's thought experiment [Phys. Rev. Lett. {\bf 68}, 2981 (1992)], using photons. The experiment consists of a pair of Mach-Zehnder interferometers that interact through photon bunching at a beam splitter.
Christoph Simon +6 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Counterfactual Thinking and Thought Experiments [PDF]
, 2014 As part of Timothy Williamson’s inquiry into how we gain knowledge from thought experiments he submits various ways of representing the argument underlying Gettier cases in modal and counterfactual terms.
Turkewitz, Josh
core
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
, 2015 We extend the existing enumeration of neck tie-knots to include tie-knots with a textured front, tied with the narrow end of a tie. These tie-knots have gained popularity in recent years, based on reconstructions of a costume detail from The Matrix ...
Hirsch, Dan +4 more
core +2 more sources
Thought Without Language: Thought Without Awareness?
Royal Institute of Philosophy Supplement, 1997 Some philosophers have laid down rather severe strictures on whether there can be thought without language. Wittgenstein asserted that ‘the limits of language…mean the limits of my world’ (1922, §5.62). Davidson (1984, p. 157) has argued that ‘a creature cannot have thoughts unless it is an interpreter of the speech of another’. Dummett (1978, p.
openaire +2 more sources
Nature Methods, 2010 The community of scientists should celebrate the Nobel Prize, even if awards bestowed on one discipline are associated with another discipline. A new prize might help.
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source