Results 111 to 120 of about 7,661,261 (288)

What is distinctive about human thought? [PDF]

open access: yes, 2010
Descartes famously argued that animals were mere machines, without thought or consciousness. Few would now share this view. But if other animals have conscious lives, what are they like, how do they differ from ours, and how would we ever know anything ...
Crane, Tim
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

A Thought-Reader's Thoughts

open access: yes, 2012
Although famous throughout Europe for his mind-reading skills, Stuart C. Cumberland (1857–1922) was a staunch critic of the 'rascality' of some spiritualist practices and their practitioners. He claimed that many of the séances and other events which he had experienced were merely fraudulent money-making impostures.
openaire   +2 more sources

A Thought Experiment [PDF]

open access: yes, 2013
Herewith, Justice Antonin Scalia\u27s long lost dissenting opinion in Brown v.
Seidman, Louis Michael
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

On Second Thought [PDF]

open access: yes, 2011
{Excerpt} Remembering times past stimulates the mind and helps give perspective and a sense of who we are. Social reminiscence is a gain in performance without practice.
Serrat, Olivier
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

I Thought the Earth Remembered Me [PDF]

open access: yes, 2019
The forest is teeming with activity: fungi transform dead logs into nutrients, roots entangle themselves with the earth, and strong winds break resilient boughs. Like the forest, the human body functions according to a complex system of agents - from the
Bates, Hannah
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

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