Results 61 to 70 of about 15,741,924 (247)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Holography and photopolymer recording materials [PDF]

, 2010
Paper presented at Fundamental Advances in Holography II (DMB), Digital Holography and Three-Dimensional Imaging (DH) conference, Miami, Florida, April 11, 2010Photopolymers act as drivers and enabler of fabrication technologies for applications ...
John T. Sheridan, Sheridan, John T.
core   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Three-dimensional imaging for hepatobiliary and pancreatic diseases: Emphasis on clinical utility

Indian Journal of Radiology and Imaging, 2009
Three-dimensional (3D) imaging allows disease processes and anatomy to be better understood, both by radiologists as well as physicians and surgeons. 3D imaging can be performed with USG, CT scan and MRI, using different modes or rendering that include ...
Soo Jin Kim, Byung Ihn Choi, Se Hyung Kim, Jae Young Lee   +3 more
doaj   +1 more source

Simple method for sub-diffraction resolution imaging of cellular structures on standard confocal microscopes by three-photon absorption of quantum dots [PDF]

, 2013
This study describes a simple technique that improves a recently developed 3D sub-diffraction imaging method based on three-photon absorption of commercially available quantum dots.
Heidbreder, Meike, Mike Heilemann, Heilemann, M., Kaltschmidt Christian, Widera, D., Stefan Hauser, Darius Widera (30596), Christian Kaltschmidt, Cseresnyes, Z., Heidbreder Meike, Anje Sporbert, Stefan Hauser (356140), Sporbert Anje, Kaltschmidt, Christian, Kaltschmidt, B., Anje Sporbert (59307), Cseresnyes Zoltan, Heidbreder, M., Kaltschmidt, Barbara, Petra Domaing, Christian Kaltschmidt (30599), Zoltan Cseresnyes (110362), Darius Widera, Hauser Stefan, Kaltschmidt Barbara, Domaing, P., Mike Heilemann (5654950), Sporbert, A., Sporbert, Anje, Widera, Darius, Widera, Darius ; https://orcid.org/, Widera Darius, Barbara Kaltschmidt (30598), Petra Domaing (59308), Meike Heidbreder (414264), Hauser, Stefan, Meike Heidbreder, Barbara Kaltschmidt, Hauser, S., Kaltschmidt, C., Zoltan Cseresnyes, Cseresnyes, Zoltan, Heilemann, Mike, Domaing Petra, Heilemann Mike, Domaing, Petra   +45 more
core   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Nuove metodologie di studio dell'anatomia del sistema nervoso centrale in cadavere mediante tecniche di neuroimmagine, modelli computazionali e ricostruzioni tridimensionali. Sviluppo e future applicazioni per i principali approcci neurochirurgici [PDF]

, 2011
The goal of the present study was to develop a computer based three-dimensional (3D) anatomical and geometrical model of neurosurgical approaches. Such model can be employed for teaching surgical anatomy, developing surgical guidelines and provide for an
De Notaris, Matteo
core   +1 more source