Results 81 to 90 of about 15,741,924 (247)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Photoacoustic imaging of cells in a three-dimensional microenvironment

Journal of Biomedical Science, 2020
Imaging live cells in a three-dimensional (3D) culture system yields more accurate information and spatial visualization of the interplay of cells and the surrounding matrix components compared to using a two-dimensional (2D) cell culture system. However,
Wei-Wen Liu, Pai-Chi Li
doaj   +1 more source

Three-Dimensional (3D) Imaging Technology to Monitor Growth and Development of Holstein Heifers and Estimate Body Weight, a Preliminary Study. [PDF]

Sensors (Basel), 2022
Le Cozler Y, Brachet E, Bourguignon L, Delattre L, Luginbuhl T, Faverdin P.   +5 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas

Scientific Reports
Exocrine and endocrine pancreas are interconnected anatomically and functionally, with vasculature facilitating bidirectional communication. Our understanding of this network remains limited, largely due to two-dimensional histology and missing ...
Gabriel Alexander Salg, Verena Steinle, Jonas Labode, Willi Wagner, Alexander Studier-Fischer, Johanna Reiser, Elyes Farjallah, Michelle Guettlein, Jonas Albers, Tim Hilgenfeld, Nathalia A. Giese, Wolfram Stiller, Felix Nickel, Martin Loos, Christoph W. Michalski, Hans-Ulrich Kauczor, Thilo Hackert, Christian Dullin, Philipp Mayer, Hannes Goetz Kenngott   +19 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Applications of electromagnetic metasurfaces in Three-Dimensional Imaging: A review

Materials & Design
Three-dimensional (3D) imaging technology has demonstrated its ability to capture spatial information beyond the capabilities of two-dimensional (2D) imaging, drawing significant attention in fields such as consumer electronics, autonomous driving, and ...
Hongji Duan, Zheng Li, Qi Gao, Xiaomin Liu   +3 more
doaj   +1 more source

Three-dimensional (3D) imaging of lipids in skin tissues with infrared matrix-assisted laser desorption electrospray ionization (MALDESI) mass spectrometry. [PDF]

Anal Bioanal Chem, 2021
Bai H, Linder KE, Muddiman DC.
europepmc   +1 more source

Tracking MEP installation works [PDF]

, 2013
Recent research efforts to improve construction progress tracking has focused on employing emerging technologies such as three dimensional (3D) imaging, including digital photogrammetry and 3D Terrestrial Laser Scanning (TLS). Previous research has shown
Chiamone, Tiziana, Ciribini, Angelo, F. Bosché, Haas, Carl T., T. Chiamone, Bosché, Frédéric, Vassena, Giorgio, Y. Turkan, Turkan, Yelda, C.T. Haas, G. Vassena, A. Ciribini, CIRIBINI, Angelo Luigi Camillo, Bosche F., Chiamone T., Turkan Y., VASSENA, Giorgio Paolo Maria, Yelda, Turkan, Frederic, Nicolas Boschè, Haas C. T., Ciribini A., Vassena G., Carl, Haas   +22 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source