Results 81 to 90 of about 632,952 (333)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Correlation Plenoptic Imaging With Entangled Photons

, 2016
Plenoptic imaging is a novel optical technique for three-dimensional imaging in a single shot. It is enabled by the simultaneous measurement of both the location and the propagation direction of light in a given scene.
D'Angelo, Milena, Di Lena, Francesco, Garuccio, Augusto, Pepe, Francesco V., Scarcelli, Giuliano   +4 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Three Dimensional (3D) Body Imaging for Assessment of Body Volume

The FASEB Journal, 2008
Techniques for evaluation of body volume are limited due to high cost, subject burden and/or inaccuracy. This research compared a small‐scale 3D photonic scanning imager to hydrodensitometry (HD) in order to conduct preliminary assessments of its validity. A secondary goal was to assess reproducibility of the 3D body imager. Women (
Jeanne H Freeland‐Graves, Bugao Xu, M Reese Pepper, Zhaoli Dai, Wurong Yu, Jodi M Cahill   +5 more
openaire   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The Influence of Three-Dimensional Cone Beam Computed Tomography (CBCT) Data on Decision-Making for Maxillary Impacted Canines

Applied Sciences
Although the increased use of three-dimensional (3D) cone beam computed tomography (CBCT) in orthodontic treatment, the necessity of the CBCT on treatment decision-making for maxillary impacted canines was not fully assessed compared to two-dimensional ...
Jae-Nam Lee, Ho-Jin Kim, Hyo-Sang Park
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Three-dimensional dynamic MR-hysterosalpingography; a new, low invasive, radiation-free and less painful radiological approach to female infertility [PDF]

, 2017
BACKGROUND: The purpose of this study was to propose a new method for imaging the uterine cavity and Fallopian tube patency by three-dimensional dynamic magnetic resonance hysterosalpingography (3D dMR-HSG) and to analyse if, by using a higher viscosity ...
Bongartz, G., De Geyter, C., Fröhlich, J.M., Unterweger, M., Wiesner, W.   +4 more
core  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Acquisition Method of Three Dimensional Images Based on Liquid Crystal Micro Lens Array

Medžiagotyra, 2017
This paper presents a novel method for acquiring three-dimensional (3D) images based on an electrically controlled liquid crystal (LC) micro lens array (MLA).
Fan PAN, Hui LI
doaj   +1 more source