Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Singularities of Three-Dimensional Ricci Flows
, 2016 The Ricci flow is an evolution of a Riemannian metric driven by a parabolic PDEs and was introduced by Hamilton in 1982. It has been the fundamental tool for some important achievements in geometry in the early 2000s, such as Perelman’s proof of the geometrization conjecture and Brendle–Schoen’s proof of the differentiable sphere theorem.
openaire +3 more sources
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Numerical Computation of Three Dimensional Viscous Flow of Axial Flow Runner
工程科学与技术, 2006 :In order to enhance design accuracy and performance，three dimensional viscous flow inside axial flow runner is simulated based on time averaged Navier-Stokes equations, standard k-ε turbulence model, and SIMPLEC algorithm. Predicted efficiency of axial
doaj
Large-Scale Simulation of Full Three-Dimensional Flow and Combustion of an Aero-Turbofan Engine on Sunway TaihuLight Supercomputer. [PDF]
Entropy (Basel), 2023 Xu Q +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
A three-dimensional flow model of screen channel liquid acquisition devices for propellant management in microgravity. [PDF]
NPJ Microgravity, 2022 Wang Z +6 more
europepmc +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Numerical analysis of Casson nanofluid three-dimensional flow over a rotating frame exposed to a prescribed heat flux with viscous heating. [PDF]
Sci Rep, 2022 Al-Kouz W, Owhaib W.
europepmc +1 more source