Results 51 to 60 of about 394,161 (298)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Modularized Three-Phase Semiconductor Transformer with Bidirectional Power Flow for Medium Voltage Application

Energies, 2016
This paper describes a prototype of modularized three-phase semiconductor transformer that was developed in the lab for feasibility study. The developed prototype is composed of three units of single-phase semiconductor transformer coupled in Y ...
Do-Hyun Kim, Byung-Moon Han, Jun-Young Lee   +2 more
doaj   +1 more source

Application of the SSA to the Optimal Phase-Swapping Problem in Three-Phase Asymmetric Networks

Revista UIS Ingenierías, 2023
This research addresses the optimal phase-balancing problem by applying a master-slave optimization methodology. The master stage defines the load connections per node using a discrete codification, while the slave stage evaluates each load ...
Antonny Santiago Vargas-Beltrán, Oscar Mauricio Angarita-Santofimio, Oscar Danilo Montoya-Giraldo   +2 more
doaj   +1 more source

Distribution line models analysis for loss calculation within three-phase three-wire power flow algorithms [PDF]

, 2004
Three-phase three-wire power flow algorithms, as any tool for power systems analysis, require reliable impedances and models in order to obtain accurate results.
Padilha-Feltrin, Antonio, Ochoa, Luis F., Ochoa, L.F., Ochoa, Luis F. [UNESP], Padilha-Feltrin, Antonio [UNESP], Padilha-Feltrin, A.   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Grid-tie Three-phase Inverter With Active and Reactive Power Flow Control Capability

Eletrônica de Potência, 2014
This paper proposes a methodology for the active and reactive power flow control, applied to a low voltage grid-tie three-phase power inverter. The control technique is designed by means of feedback linearization and the pole placement is obtained using
Leonardo P. Sampaio, Moacyr A. G. de Brito, Guilherme de A. e Melo, Carlos A. Canesin   +3 more
doaj   +1 more source

Application of the Vortex Search Algorithm to the Phase-Balancing Problem in Distribution Systems

Energies, 2021
This article discusses the problem of minimizing power loss in unbalanced distribution systems through phase-balancing. This problem is represented by a mixed-integer nonlinear-programming mathematical model, which is solved by applying a discretely ...
Brandon Cortés-Caicedo, Laura Sofía Avellaneda-Gómez, Oscar Danilo Montoya, Lazaro Alvarado-Barrios, Harold R. Chamorro   +4 more
doaj   +1 more source

Gamma radiation methods for clamp-on multiphase flow metering [PDF]

, 2008
The development of a cost-effective multiphase flow meter to determine the individual phase flow rates of oil, water and gas was investigated through the exploitation of a single clamp-on gamma densitometer and signal processing techniques.
Blaney, S.
core  

Comparison of DNS of Compressible and Incompressible Turbulent Droplet-Laden Heated Channel Flow with Phase Transition [PDF]

, 2018
Multiphase flows in which a large number of small droplets are dispersed in a gas, play an important role in a variety of applications. At sufficiently high mass and volume fraction the presence of the dispersed droplet phase directly modulates the flow ...
Kuerten, H., Russo, E., Armenio, Vincenzo, Geurts, B.J., Fröhlich, J., Geurts, Bernard J., Kuerten, Johannes G.M., Grigoriadis, Dimokratis G.E., Bukhvostova, A., Grigoriadis, D.G.E., Frölich, Jochen, Kuerten, J.G.M., Geurts, Bernardus J., Armenio, V.   +13 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source