Three-component radical homo Mannich reaction [PDF]
Nature Communications, 2021 Due to the ionic nature of its mechanism, the Mannich reaction can only use non-enolizable aldehydes as substrates. Here, the authors expand the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process resulting in a
Shuai Shi +5 more
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Photoinduced Synthesis of Sulfonyl-Containing Phosphorothioates via a Three-Component Reaction [PDF]
Molecules, 2023 Both sulfonyl and phosphorothioate are important privileged structural motifs which are widely presented in pharmaceuticals and agrochemicals. Herein, we describe an efficient approach to synthesizing sulfonyl-containing phosphorothioates by merging ...
Xianda Wu +5 more
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Copper-Catalyzed 1,2-Amino Oxygenation of 1,3-Dienes: A Chemo-, Regio-, and Site-Selective Three-Component Reaction with O-Acylhydroxylamines and Carboxylic Acids. [PDF]
ACS Catal, 2019 A three-component reaction for 1,2-amino oxygenation of 1,3-dienes has been achieved using O-acyl hydroxylamines and carboxylic acids. The reaction occurs through copper-catalyzed amination of olefins followed by nucleophilic addition of carboxylic acids,
Hemric BN, Chen AW, Wang Q.
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Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols [PDF]
Frontiers in Chemistry, 2019 A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very ...
Nikita E. Golantsov +6 more
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Formation of diverse polycyclic spirooxindoles via three-component reaction of isoquinolinium salts, isatins and malononitrile. [PDF]
Sci Rep, 2017 The triethylamine promoted three-component reaction of N-(4-nitrobenzyl), N-ethoxycarbonylmethylisoquinolinium bromide, isatins and malononitrile in ethanol afforded spiro[indoline-3,2′-pyrrolo[2,1-a]isoquinolines] in good yields and with high ...
Sun J, Shen GL, Huang Y, Yan CG.
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One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction [PDF]
Beilstein Journal of Organic Chemistry, 2016 A novel three-component reaction has been developed to assemble biologically and pharmaceutically important tetracyclic fused imidazo[1,2-a]pyridines in a one-pot fashion utilizing readily available 2-aminopyridines, isatins and isocyanides.
Bo Yang +4 more
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Mechanochemical Thiolation of α‑Imino Ketones: A Catalyst-Free, One-Pot, Three-Component Reaction [PDF]
ACS OmegaSrinivasarao Yaragorla +3 more
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Catalytic Three‐Component Ugi Reaction [PDF]
Angewandte Chemie International Edition, 2008 Perfect atom economy characterizes a novel catalytic three‐component Ugi reaction (see example). Different α‐amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst. The products will be useful for the synthesis of α‐amino acid derivatives and in diversity‐oriented
Pan, S., List, B.
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Catalytic Asymmetric Three‐Component Acyl‐Strecker Reaction. [PDF]
ChemInform, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pan, S., List, B.
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DFT Studies on the Stereoselective Three-Component Ugi Reaction
Orbital: The Electronic Journal of Chemistry, 2019 Mechanism and stereochemistry of three component Ugi reaction (3C-Ugi) were studied theoretically based on DFT calculations. Structures of reagents, products, intermediates, and transition states were optimized at M062X/6-31+g(d,p) level of theory in gas
Elaheh Sadat Sharifzadeh +1 more
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