Results 61 to 70 of about 519,248 (315)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

High-resolution three-dimensional flow measurement through dual-frame light field particle tracking velocimetry [PDF]

Single-camera light field particle image velocimetry (LF-PIV) shows potential for three-dimensional (3D) flow measurements in scenarios with limited optical access but faces challenges of low spatial resolution.
Hossain, Md. Moinul, Xu, Chuanlong, Zhu, Xiaoyu, Khoo, Boo Cheong   +3 more
core   +1 more source

Melnikov Theory for Two-Dimensional Manifolds in Three-Dimensional Flows

SIAM Journal on Applied Dynamical Systems, 2022
39 pages, 17 ...
Priyankara, K.G.D.S., Balasuriya, S., Bollt, E.M.   +2 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Three dimensional frequency-domain solution method for unsteady turbomachinery flows [PDF]

, 2003
The three-dimensional calculation of unsteady flows is increasingly gaining importance in the prediction of turbomachinery flow problems. A three-dimensional Euler/Navier-Stokes solver incorporating the time-linearized method and the nonlinear harmonic ...
Vasanthakumar, Parthasarathy
core  

Transient growth in the flow past a three-dimensional smooth roughness element [PDF]

, 2013
This work provides a global optimization analysis, looking for perturbations inducing the largest energy growth at a finite time in a boundary-layer flow in the presence of smooth three-dimensional roughness elements.
DE TULLIO, Marco, PASCAZIO, Giuseppe, DE PALMA, Pietro, CHERUBINI, Stefania, DE TULLIO, Marco Donato   +4 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Experimental and Computational Investigation of an “Open” Transonic Cavity Flow [PDF]

, 2009
This paper presents an investigation of a transonic flow (M∞ = 0.85) over a rectangular cavity having a length-to-depth ratio of 5. Velocities were measured inside the cavity on the central plane and two off-centre planes using a two-component particle ...
Knowles, Kevin, Atvars, K., Ritchie, S. A., Lawson, Nicholas J.   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Three-dimensional unsteady flow in the oscillating turbine blade row [PDF]

, 2006
This thesis documents an experimental and computational study of the unsteady flow around oscillating blades in low-pressure turbines, with emphasis on the three- dimensional flow behaviour, intra-row interaction effects, tip clearance flow and part ...
Huang, Xiuquan
core