Results 41 to 50 of about 22,068 (253)

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Fluoroless cavotricuspid isthmus ablation of typical atrial flutter achieves success with shorter radiofrequency and procedural times

Revista Portuguesa de Cardiologia
Introduction and objectives: Cavotricuspid isthmus (CTI) ablation for typical atrial flutter (AFL) has improved in recent years, especially with three-dimensional (3D) electroanatomic mapping systems.
Sofia Jacint, Guilherme Portugal, Hélder Santos, Pedro Silva Cunha, Bruno Valente, Ana Lousinha, Ana Sofia Delgado, Rui Cruz Ferreira, Mário Martins Oliveira   +8 more
doaj   +1 more source

Quantum flutter of supersonic particles in one-dimensional quantum liquids

, 2012
The non-equilibrium dynamics of strongly correlated many-body systems exhibits some of the most puzzling phenomena and challenging problems in condensed matter physics.
A Imambekov, A Imambekov, A Kamchatnov, A Lamacraft, AC Hewson, AG Sykes, AS Alexandrov, AY Cherny, B-H Liu, C Kohstall, C Latta, C Weitenberg, Charles J. M. Mathy, D Chruściński, E Haller, Eugene Demler, F Chevy, GE Astrakharchik, GS Engel, H Castella, HP Büchler, I Carusotto, J Catani, J Meineke, J-S Caux, L Rutherford, M Girardeau, M Koschorreck, M Olshanii, M Schecter, MB Zvonarev, MB Zvonarev, MD Girardeau, Mikhail B. Zvonarev, N Strohmaier, P Barmettler, P Nozières, R Combescot, S Diehl, S Giraud, S Loth, S Nascimbène, S Palzer, S Trotzky, T Kinoshita, T Kinoshita, TH Johnson, V Hakim, V Ngampruetikorn, Y Liao   +49 more
core   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Nonlinear flutter of curved plates, part 2 [PDF]

Numerical results for nonlinear flutter analysis of three dimensional curved ...
Dowell, E. H.
core   +1 more source

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

Advanced Science, EarlyView.
Cyclic nucleotide‐gated (CNG) and hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels share substantial sequence and structural similarity but differ markedly in ion conductance and K+ selectivity. Microsecond‐scale atomistic MD simulations qualitatively reproduced the conductance differences observed in single‐channel recordings and ...
Haoran Liu, Klaus Benndorf, Yessenbek K. Aldakul, Han Sun   +3 more
wiley   +1 more source

Prediction of transonic flutter for a supercritical wing by modified strip analysis and comparison with experiment [PDF]

Use of a supercritical airfoil can adversely affect wing flutter speeds in the transonic range. As adequate theories for three dimensional unsteady transonic flow are not yet available, the modified strip analysis was used to predict the transonic ...
Desmarais, R. N., Farmer, M. G., Wynne, E. C., Yates, E. C., Jr.   +3 more
core   +1 more source

Paper waves in the wind

, 2015
A flexible sheet clamped at both ends and submitted to a permanent wind is unstable and propagates waves. Here, we experimentally study the selection of frequency and wavenumber as a function of the wind velocity.
Andreotti, Bruno, Claudin, Philippe, Jia, Pan   +2 more
core   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source