Results 101 to 110 of about 33,716,273 (299)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Adaptive system of identification of parameters of asynchronous three-phase motor

Известия высших учебных заведений: Проблемы энергетики, 2017
On the basis of the continuous gradient a method of search of a minimum of function the algorithm of identification of parameters of three-phase asynchronous motor is developed. Computer modeling of processes of identification allowed to reveal essential
A. J. Afanasiev, V. G. Makarov, Y. A. Yakovlev, V. N. Khannanova   +3 more
doaj   +1 more source

Wetting Behavior of a Three-Phase System in Contact with a Surface. [PDF]

Macromolecules, 2022
Mukherjee B, Chakrabarti B.
europepmc   +1 more source

Phase Separation Dynamics in Oil-Polyethylene Glycol-Sulfate-Water Based Three-Liquid-Phase Systems

, 2015
Phase separation dynamic processes in three-liquid-phase system (TLPS), composed of organic oil (P507 extractant), water-soluble polymer (PEG2000), ammonium sulfate, and water, with the change of mass composition Of phase-forming components were ...
Xiao, Chuanxu, Liu, Huizhou, Lin, Jieyuan, Suo, Zhicheng, Li, Xiaopei, Huang, Kun   +5 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Effect of Annealing on Structural-phase State and Three-layered Film Magnetoresistance Systems Based on Ni and V as well as Ni and Au or Ag [PDF]

Журнал нано- та електронної фізики, 2016
The structural-phase state and magnetoresistive properties of three-layer film systems based on Ni and V and Ni and Au or Ag total thickness d = 25-55 nm thick steel spacer ds = 5 nm. Experimentally tested the influence of annealing temperatures from 300
T.M. Grychanovs’ka, T.S. Kholod, O.A. Hrychanovs’ka, L.A. Tsygankova   +3 more
doaj  

Three-phase study design.

, 2023
The International Society for Physical Activity and Health advocates for increased capability of the physical activity workforce as a key ingredient to a system-based approach.
Jamie Crowther (17067814), Sufyan Abid Dogra (11853654), Emma S. Young (17067808), Andy Daly-Smith (8405337), Isobel P. Steward (17067805), Jennifer Hall (3489161), Elizabeth Stamp (9512348), Kelly Morgan (484251), Kammy Siddique (17067811)   +8 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source