Results 171 to 180 of about 514,103 (332)

m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

open access: yesAdvanced Science, EarlyView.
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li   +8 more
wiley   +1 more source

Supplementing low protein diets with methionine or threonine during mixed Eimeria challenge

open access: yesPoultry Science
: We investigated the effects of supplementing low protein diets with methionine (Met) or threonine (Thr) during a mixed Eimeria (consisting of E. acervulina, E. maxima and E. tenella) challenge in broilers. All birds were fed the same starter diet (d1–9)
James Taylor   +8 more
doaj  

Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation

open access: yesAdvanced Science, EarlyView.
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu   +8 more
wiley   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

open access: yesAdvanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu   +9 more
wiley   +1 more source

Distribution of soluble amino acids in maize endosperm mutants

open access: yesScientia Agricola, 2003
For human nutrition the main source of vegetable proteins are cereal and legume seeds. The content of total soluble amino acids in mature endosperm of wild-type, opaque and floury maize (Zea mays L.) mutants were determined by HPLC.
Toro Alejandro Alberto   +4 more
doaj  

Direct and Low‐Temperature Regeneration of Degraded LiFePO₄ Cathodes at Ambient Conditions Using Green and Sustainable Deep Eutectic Solvent

open access: yesAdvanced Science, EarlyView.
Computational predictions identify ethylene glycol and lithium chloride as optimal components for a green deep eutectic solvent (DES). And further investigations determine the optimal reaction conditions and process parameters for DES treatment of spent lithium iron phosphate (S‐LFP).
Yixin Lin   +7 more
wiley   +1 more source

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