Results 201 to 210 of about 548,221 (334)

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

XIAP down-regulation inhibits RIPK2 ubiquitination-mediated insulin resistance. [PDF]

Endocr Connect
Zhao C, Zhang Z, Li R, Geng X.
europepmc   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Metabolic Predictors of CAD: Focus on Cystine, Methionine, Proline, and Threonine Circulating Levels-Exploratory Pilot Study. [PDF]

J Clin Med
Urbanowicz T, Pietkiewicz D, Plewa S, Krasińska B, Spasenenko I, Gabriel K, Jezierska K, Krasiński Z, Kowalewski M, Matysiak J, Tykarski A.   +10 more
europepmc   +1 more source

A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs

, 2019
Lulu Zhao, Xinyu Yuan, Jubo Wang, Yifan Feng, Fei Ji, Zhiyu Li, Jinlei Bian   +6 more
openalex   +1 more source

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

Interrelationships of Certain Metabolic Responses to Threonine Deficiency and to Various Dietary Carbohydrates in the White Rat [PDF]

, 1965
Bright, Elizabeth
core   +2 more sources

Targeted metabolomics to quantitatively profile changes in amino acids and phenolics at every step of <i>amahewu</i> production from two <i>Zea Mays</i> L. maize types (white and yellow). [PDF]

Front Nutr
Kgoale SD, Jimoh AA, Tugizimana F, Abrahams A, Adebo OA.   +4 more
europepmc   +1 more source

Serine/threonine protein phosphatases [PDF]

Biochemical Journal, 1995
S, Wera, B A, Hemmings
openaire   +2 more sources

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source