Results 211 to 220 of about 611,533 (383)

Emerging serine-threonine kinase inhibitors for treating ovarian cancer

, 2019
Asaf Maoz, Marcia A. Ciccone, Shinya Matsuzaki, Robert L. Coleman, Koji Matsuo   +4 more
openalex   +2 more sources

Mechanism of Lenvatinib Resistance via Exosomal miRNA‐132/Nrf2 Axis in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Exosomal miRNA‐132 from LVT‐res HCC cells activated Nrf2 expression through the PTEN/GSK3β pathway in recipient cells. This cascade could induce drug resistance in non‐resistant HCC cells in the TME. ABSTRACT Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC ...
Chie Takasu, Chiharu Nakasu, Yu Saito, Yuji Morine, Tetsuya Ikemoto, Shinichiro Yamada, Hiroki Teraoku, Mitsuo Shimada   +7 more
wiley   +1 more source

Editorial: Structure and mechanism of microbial membrane active transporters. [PDF]

Front Microbiol
Jiang X, Smallwood CR, Klebba PE, Bonaccorsi di Patti MC.   +3 more
europepmc   +1 more source

A Generic Time-resolved Fluorescence Assay for Serine/threonine Kinase Activity: Application to Cdc7/Dbf4 [PDF]

, 2003
Kui Xu, A S Stern, Wayne Levin, Anne O. Chua, Lyubomir T. Vassilev   +4 more
openalex   +1 more source

Threonine deficiency decreased intestinal immunity and aggravated inflammation associated with NF-κB and target of rapamycin signalling pathways in juvenile grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila

British Journal of Nutrition, 2017
Yu-Wen Dong, Wei‐dan Jiang, Yang Liu, Pei Wu, Jun Jiang, S. Kuang, Ling Tang, Wuneng Tang, Yong‐An Zhang, Xiao‐qiu Zhou, Lin Feng   +10 more
semanticscholar   +1 more source

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

Propanol production through microbial fermentation of biomass. [PDF]

Bioresour Bioprocess
Sun C, Yang L, Zhao C, Li H, Deng Z, Liu G, Wu C.   +6 more
europepmc   +1 more source

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

Diabetologia, 2012
Kyle D. Copps, M. White
semanticscholar   +1 more source

The HRAS Variant c.175G>A (p.Ala59Thr) Causes a Predominantly Ectodermal Phenotype Lacking Classic Costello Syndrome Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Costello syndrome (CS) is a rare dominant HRAS RASopathy characterized by curly hair, cardiac abnormalities, craniofacial anomalies, and developmental delay. HRAS codon 58, 59, and 60 variants are associated with milder phenotypes. We describe a three‐generation family with a previously unreported heterozygous HRAS variant c.175G>A (p.Ala59Thr)
Nikole Rautiainen, Eveliina Brandt, Kaisa Kettunen, Outi Elomaa, Sirpa Kivirikko, Leila Jeskanen, Katriina Lappalainen, Nelli Sjöblom, Juha Kere, Katariina Hannula‐Jouppi, Liisa Harjama   +10 more
wiley   +1 more source

Post-translational modifications via serine/threonine phosphorylation and GpsB in <i>Streptococcus mutans</i>. [PDF]

mSystems
Chudal S, Dover C, Haydt T, King SM, Shields RC.   +4 more
europepmc   +1 more source