Markerless mutagenesis enables isoleucine biosynthesis solely from threonine in <i>Methanothermobacter marburgensis</i>. [PDF]
Klein M+6 more
europepmc +1 more source
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu+12 more
wiley +1 more source
Methionine, threonine and glutamic acid adapted pathways in captive cheetahs on a glycine-supplemented diet. [PDF]
van Boom KM, Kohn TA, Tordiffe ASW.
europepmc +1 more source
Promising Prodiginins Biological Activities
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto+6 more
wiley +1 more source
Sequential Michael addition, cross-coupling and [3 + 2] cycloaddition reactions within the coordination sphere of chiral Ni(ii) Schiff base complexes derived from dehydroamino acids: pathways to the asymmetric synthesis of structurally diverse <i>O</i>-substituted serine and threonine analogs. [PDF]
Khachatryan EA+8 more
europepmc +1 more source
Threonine Synthetase Mechanism: Studies with Isotopic Oxygen
Martin Flavin, Tetsuro Kôno
openalex +1 more source
A tailored phospho‐p53 library probes antibody specificity and recognition limitations
The tumour suppressor protein p53, known as the "guardian of the genome", is regulated by a complex network of posttranslational modifications (PTMs). Phosphorylations at 7 Ser/Thr residues within the N‐terminal transactivation domain 1 (TAD1) play a role in p53 activation, yet their precise mechanisms of action remain elusive due to challenges in ...
Mateusz Hess+6 more
wiley +1 more source
Effects of maternal dietary threonine concentrations on the productive performance, amino acid profile in plasma and eggs of laying duck breeders, and performance of ducklings one-week post-hatching. [PDF]
Azzam MM+8 more
europepmc +1 more source
ABSTRACT Background and Objectives This study evaluated the effect of seed protein content on the composition, physicochemical, functional, and quality properties of pea protein isolates recovered through alkaline extraction/isoelectric precipitation.
Cassia Galves+4 more
wiley +1 more source