Results 261 to 270 of about 604,484 (380)

Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

EMBO Journal, 1997
A. Waskiewicz, A. Flynn, C. Proud, Jonathan A. Cooper   +3 more
semanticscholar   +1 more source

Alkaline–Acid Intestine Environment Controlled by A Carbonic Anhydrase Gene Influences Synthesis of Sex Pheromone by Symbionts

Advanced Science, EarlyView.
A model proposing that elevated rectal expression of CAh1 in males alkalinizes the environment to regulate Bacillus production of a male‐specific sex pheromone. Abstract The intricate interplay between animals and their intestinal microbes is pivotal in shaping various aspects of animal biology.
Shiyu Gui, Lexin Xie, Zhenghao Wang, Yan Chen, Yi Xiao, Ziyun Lin, Jingxiang Chen, Yongyue Lu, Laurent Keller, Daifeng Cheng   +9 more
wiley   +1 more source

Profiling of Diverse Pyridoxal-5'-Phosphate Dependent Enzymes Reveals Promiscuous Aldolase Activity with (2-Azaaryl)methanamines. [PDF]

J Am Chem Soc
Smith KL, Arbuckle MA, Kim AT, Tsai CY, McIntosh JA, Verma D, Shim E, Narayan ARH.   +7 more
europepmc   +1 more source

Leveraging 3D Molecular Spatial Visual Information and Multi‐Perspective Representations for Drug Discovery

Advanced Science, EarlyView.
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang, Xi Zhou, Yujie Qi, Xiaobo Zhu, Xun Deng, Feng Tan, Yuan Huang, Lun Hu, Zhuhong You, Pengwei Hu   +9 more
wiley   +1 more source

In vitro and molecular modeling insights into α-amylase inhibition by tamarind seed-derived trypsin inhibitor: Implications for hyperglycemic control. [PDF]

PLoS One
de Souza LAL, de Souza Sena CP, de Macêdo Oliveira FC, Serquiz RP, Aguiar AJFC, de Souza Nascimento AM, de Gois Silva AKX, de Paiva Chaves R, Santana Luz AB, Passos TS, Vieira DS, Morais AHA.   +11 more
europepmc   +1 more source

Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

EMBO Journal, 1996
Takeshi Matsui, M. Amano, Takaharu G. Yamamoto, K. Chihara, M. Nakafuku, M. Ito, T. Nakano, K. Okawa, A. Iwamatsu, K. Kaibuchi   +9 more
semanticscholar   +1 more source

Autophagy‐Targeting Fe–Cu Nanozyme for Tumor Immune Microenvironment Remodeling and Image‐Guided Cancer Immunotherapy

Advanced Science, EarlyView.
In this study, a multifunctional iron‐copper metal–organic framework nanozyme platform co‐delivering chloroquine and perfluorohexane is engineered to circumvent tumor immune evasion by disrupting autophagic flux and restoring major histocompatibility complex class I presentation. This dual‐action nanoplatform orchestrates synergistic autophagy blockade
Li Yan, Chao Chen, Yu Liang, Xiaowan Huang, Jieying Qian, Hao Zhang, Li Zhang, Yingjia Li, Yunjiao Zhang   +8 more
wiley   +1 more source

Deciphering the metabolic patterns of cashew apple ripening process: A comprehensive non-targeted metabolomics analysis. [PDF]

Food Chem (Oxf)
Huang H, Zhao L, Huang W, Feng X, Hu F, Zhao Y, Li H, Peng Y, Wang Y, Zhang Z, Liu Y.   +10 more
europepmc   +1 more source

T‐2 Toxin Exploits Gut‐Derived Staphylococcus Saprophyticus to Disrupt Hepatic Macrophage Homeostasis

Advanced Science, EarlyView.
T‐2 toxin promotes the proliferation of intestinal S. saprophyticus and facilitates its translocation to the liver in piglets and mice. The translocated bacteria trigger autophagy in Kupffer cells and recruit monocytes to the liver through the nucleotide‐binding oligomerization domain 2 (NOD2) signaling pathway, alongside the M1 polarization of hepatic
Yuanyuan Zhu, Liu Xu, Fangrui Guo, Jianyu Qu, Xiangyan Liu, Qiurong Xu, Jie Sheng, Jiangping Wang, Xiaohong Xie, Ruimin Ren, Chuan Zhou, Sisi Yan, Shuiping Liu, Zhihang Yuan, Rongfang Li, Jing Wu, Jine Yi, Yulong Yin, Lixin Wen, Ji Wang   +19 more
wiley   +1 more source

O-GlcNAcase Inhibitor Improves Denervation-Induced Muscle Atrophy in Mice. [PDF]

J Cachexia Sarcopenia Muscle
Suenaga T, Matsushima S, Masunaga T, Hashimoto T, Takada S, Fumoto Y, Hata S, Abe K, Kinugawa S.   +8 more
europepmc   +1 more source