Results 301 to 310 of about 604,484 (380)

The Mechanism of Action of 5'-Adenylic Acid-activated Threonine Dehydrase

, 1968
P.D. Whanger, Allen T. Phillips, K.W. Rabinowitz, Jeanette R. Piperno, J.D. Shada, W.A. Wood   +5 more
openalex   +1 more source

Frequency of Microvascular Pathology and Hippocampal Atrophy on Magnetic Resonance Imaging in a Community Study of Alzheimer's Disease with Blood‐Based Biomarkers

Annals of Neurology, EarlyView.
Objective Blood‐based biomarkers for Alzheimer's disease (AD), representing antemortem indicators of AD pathophysiology, have greatly improved the accuracy of diagnosis. However, these biomarkers may not capture a frequent coincident pathology, such as cerebrovascular disease.
Tamil Iniyan Gunasekaran, Danurys Sanchez, Dolly Reyes‐Dumeyer, Rabel Ventura, Clarissa Morales, Mohamad Alshikho, Annie J. Lee, Rafael A. Lantigua, Yian Gu, Lawrence S. Honig, Badri N. Vardarajan, Adam M. Brickman, Richard Mayeux   +12 more
wiley   +1 more source

Impact of Glycoclustering on Stiffening of MUC5AC Peptides Revealed by High‐Efficiency Synthesis

Angewandte Chemie, EarlyView.
Peptides featuring a previously unattained degree of glycoclustering were obtained by fully automated solid‐phase synthesis in 1,3‐dioxolane/Tween‐20 and diselenide–selenoester ligation. Circular Dichroism (CD) and Pulsed Electron‐Electron Double Resonance (PELDOR) measurements of densely GalNAcylated MUC5AC multi‐tandem repeat peptides provided ...
Arseniy Galashov, Elisabetta di Gregorio, Polina Ponomareva, Marc Safferthal, Ekaterina Kazakova, Leïla Bechtella, Kevin Pagel, Marina Pigaleva, Benesh Joseph, Oliver Seitz   +9 more
wiley   +2 more sources

Identification and genetic analysis of candidate genes for resistance against <i>Phytophthora sojae</i> in soybean using a genome-wide association study. [PDF]

Front Plant Sci
Park HR, Heo SV, Kang BK, Seo H, Lee E, Park J, Jang YW, Seo JH, Park G, Kim JH, Lee YH, Han WY, Seo MC, Jeung JU.   +13 more
europepmc   +1 more source

Fatty acid composition of portal fatty liver in lysine- and threonine-deficient rats

, 1964
Roberto Viviani, Anna Maria Sechi, Giorgio Lenaz   +2 more
openalex   +1 more source

Identification of New KCNT1‐Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling

Annals of Neurology, EarlyView.
Objective Hyperactive KCNT1 potassium channels, caused by gain‐of‐function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug‐resistant seizures and, in cases with infantile onset, developmental regression can follow.
Michael G. Ricos, Bethan A. Cole, Rashid Hussain, Grigori Y. Rychkov, Zeeshan Shaukat, Nadia Pilati, Stephen P. Muench, Katie J. Simmons, Leanne M. Dibbens, Jonathan D. Lippiat   +9 more
wiley   +1 more source

High‐Throughput Engineering and Modification of Non‐Ribosomal Peptide Synthetases Based on Golden Gate Assembly

Angewandte Chemie, EarlyView.
A Golden Gate Assembly (GGA)‐based method was developed for the efficient assembly of natural and engineered non‐ribosomal peptide synthetases (NRPS). This method has enabled the creation of NRPS libraries to generate novel peptides in high‐throughput as well as the targeted derivatisation of natural products (NPs).
Adrian Podolski, Timon A. Lindeboom, Leonard Präve, Maryam Dehghan, Hannah A. Minas, Janik Kranz, Daniel Schindler, Helge B. Bode   +7 more
wiley   +2 more sources

Blood-based pre-screening in the SKYLINE secondary prevention Ph3 gantenerumab study. [PDF]

Alzheimers Dement
Bauer A, Rabe C, Schiffman C, Rose F, Respondek G, Gullotta F, Schlieker L, Jethwa A, Schrurs I, Manuilova E, Ostrowitzki S, Bittner T.   +11 more
europepmc   +1 more source

Time Cource of Tissue Free Amino acid Concentration and of the Incorporation of C14-threonine into Tissue Proteins of Rats Fed on a Diet Containing Balanced Amino acid Mixture (Part 1)

, 1969
Katsuhiko Noda, Keiko Moritoki, Shigeru Yamamoto, Akira Yoshida   +3 more
openalex   +2 more sources

Approaches to Enhance Photodynamic Therapy of Lung Cancer: Potential Application of Nanoparticles

Advanced NanoBiomed Research, EarlyView.
Bioactive ligand‐targeted nanocarriers can accommodate functionalization with numerous targeting ligands for effective delivery of photosensitizers (PSs) within targeted photodynamic therapy. Various targeting moieties including peptides, antibodies, carbohydrates, aptamers, proteins, and PS anticancer molecules can be attached to nanomaterials.
Nokuphila Winifred Nompumelelo Simelane, Heidi Abrahamse   +1 more
wiley   +1 more source