Results 171 to 180 of about 3,647,403 (348)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

EFFECT OF EXERCISE AT INTENSITIES AROUND VENTILATORY THRESHOLD ON PLASMA PROTEIN-BOUND SULFHYDRYL GROUPS

, 1997
Makoto Saito, Takayo Inayama, Seiji Maeda, Mitsuo Matsuda   +3 more
openalex   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Near-threshold fatigue crack propagation behavior and frequency effect for Cr-Mo-V steel at an elevated temperature.

, 1987
Etsuo TAKEUCHI, Saburo MATSUOKA, Satoshi NISHIJIMA   +2 more
openalex   +2 more sources

The impact of innovation on CO2 emissions: The threshold effect of financial development

, 2022
Danni Yu, Wei Ni Soh, Bany Ariffin Amin Noordin, Mohamed Hisham Dato Haji Yahya, Badar Latif   +4 more
openalex   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Association of Vitamin D Levels and Mortality in Overactive Bladder: Nonlinear Dose-Response and Threshold Effect. [PDF]

Food Sci Nutr
Yang C, Shen N, Xiao H, Zhao Z, Yang Q, Liu Y, Lai D.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Threshold Effect of Anxiety in the Comorbidity of Depression and Chronic Pain: A Cross-Sectional Study Based on Pain Sensitivity. [PDF]

Neuropsychiatr Dis Treat
Liu Y, Cheng J, Gao H, Chen Y, Chen H, Xia Q, Yan J, Li C, Ju P, Zhu C.   +9 more
europepmc   +1 more source

Threshold Effect of Tio₂ Nanoparticles on the Tribological Properties of Uhmwpe Composites in Dual Environments: Microstructure-Wear Mechanism Relationship

Xiaobo Nie, Zhong Wen, Yongqing Tang, Xuan Liu, Siqiang Chen   +4 more
openalex   +1 more source