Results 151 to 160 of about 3,647,403 (348)

Spatial differentiation and driving mechanisms of the Water-Energy-Food-Carbon coupling coordination degree in China

Shui kexue jinzhan
Dual Carbon Goals and resource constraints make it important to understand the evolutionary characteristics and driving mechanisms of the Water-Energy-Food-Carbon（WEFC） nexus. We propose a spatially adaptive coupling evaluation（SPACE） model that combines
Nan LIU, Baohui MEN, Xiaoyu HAN, Xiaolu XU, Xiaomeng YUAN, Hongrui WANG   +5 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Do Financial Incentives for Firms Promote Employment of Disabled Workers? A Regression Discontinuity Approach [PDF]

We study the impact of employment quota on firms' demand for disabled workers. The Austrian Disabled Persons Employment Act (DPEA) requires firms to provide at least one job to a disabled worker per 25 non-disabled workers, a rule which is strictly ...
Jean-Philippe Wuellrich, Josef Zweimüller, Rafael Lalive   +2 more
core  

Photoinitiators for two-photon polymerisation: effect of branching and viscosity on polymerisation thresholds

, 2017
Reece Whitby, Yael Ben‐Tal, Ryan MacMillan, S. Janssens, Sebastiampillai G. Raymond, Dave Clarke, Jianyong Jin, Andrew J. Kay, M. Cather Simpson   +8 more
openalex   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Effect of phase modulation on linewidth and stimulated Brillouin scattering threshold of narrow-linewidth fiber amplifiers

, 2017
Yakun Liu, Wang Xiao-Lin, Su Rong-Tao, Pengfei Ma, Zhang Han-wei, Zhou Pu, Lei Si   +6 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

The effect of Stimulus-Duration on the EGM-Thresholds. Qualitative or quantitative methods?

, 2019
Pavlos Pavlidis, RJA Cámara, Omid Majdani, G Kekes, Haralampos Gouveris   +4 more
openalex   +1 more source

Effect of soil leaching on the toxicity thresholds (ECx) of Zn in soils with different properties

, 2021
Luyao Qin, Meng Wang, Shuwen Zhao, Shanshan Li, Xiaoqin Lei, Lifu Wang, Xiaoyi Sun, Shibao Chen   +7 more
openalex   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source