Results 11 to 20 of about 3,607,125 (302)
Mitochondrial threshold effects [PDF]
The study of mitochondrial diseases has revealed dramatic variability in the phenotypic presentation of mitochondrial genetic defects. To attempt to understand this variability, different authors have studied energy metabolism in transmitochondrial cell lines carrying different proportions of various pathogenic mutations in their mitochondrial DNA. The
Rodrigue, Rossignol +5 more
openaire +2 more sources
Challenges of calculating cost-effectiveness thresholds [PDF]
Contains fulltext : 296650.pdf (Publisher’s version ) (Open Access)
Angel, Paternina-Caicedo +2 more
openaire +6 more sources
NICE's cost effectiveness threshold [PDF]
The recent judicial review instigated by the drug companies Pfizer and Eisai concerning National Institute for Health and Clinical Excellence (NICE) guidance,1 which would deny access to three drugs for patients with mild Alzheimer's disease, and a second ongoing inquiry into NICE by the House of Commons Health Select Committee,2 are the latest ...
Appleby, John +2 more
openaire +3 more sources
THRESHOLD EFFECTS AND PERTURBATIVE UNIFICATION [PDF]
We discuss the effect of the renormalization prescription in the computation of the unification point for running coupling constants. We explore the effects of threshold crossing on the β functions. We compute the running of the coupling constants of the Standard Model, between mz and Mp, using a mass-dependent subtraction procedure, and then compare ...
Bastero Gil, M. +2 more
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Threshold Effects in Cointegrating Relationships* [PDF]
AbstractIn this paper, we introduce threshold‐type nonlinearities within a single‐equation cointegrating regression model and propose a testing procedure for testing the null hypothesis of linear cointegration vs. cointegration with threshold effects. Our framework allows the modelling of long‐run equilibrium relationships that may change according to ...
Gonzalo, Jesús, Pitarakis, Jean-Yves
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Nonperturbative effect in threshold resummation [PDF]
JHEP06(2009 ...
Li, Chong Sheng, Li, Zhao, Yuan, C. -P.
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Threshold effects in charm hadroproduction [PDF]
20 pages, 10 figures, new pion PDFs used, some discussion added, conclusions ...
Kidonakis, N. +3 more
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The Price of Cost-Effectiveness Thresholds
Health systems around world are increasingly adopting cost-effectiveness (CE) analysis to inform decisions about access and reimbursement. We study how CE thresholds imposed by a health plan for granting reimbursement affect drug producers pricing incentives and patients access to new drugs. Analysing a sequential pricing game between an incumbent drug
Brekke, Kurt R. +2 more
openaire +3 more sources
Cost-effectiveness thresholds or decision-making threshold: a novel perspective
AbstractThe use of multiple cost-effectiveness thresholds in pharmacoeconomic evaluation is a hotly debated topic in the international academic community. This study analyzed and discussed thresholds in the context of pharmacoeconomic evaluation and reimbursement decision-making.
Lihua Sun +3 more
openaire +3 more sources
Cost–effectiveness thresholds: pros and cons [PDF]
Cost-effectiveness analysis is used to compare the costs and outcomes of alternative policy options. Each resulting cost-effectiveness ratio represents the magnitude of additional health gained per additional unit of resources spent. Cost-effectiveness thresholds allow cost-effectiveness ratios that represent good or very good value for money to be ...
Bertram, Melanie Y. +6 more
openaire +3 more sources

