Results 71 to 80 of about 12,065,388 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Threshold Effect in the Street Vitality Formation Mechanism

ISPRS International Journal of Geo-Information
Street vitality has become a crucial metric for smart city management. Classical theories qualitatively explain that street vitality originates from the dynamic interaction between people and spatial carriers, yet the threshold effect within this process
Yilin Ke, Jiawen Wang, Shiping Lin, Jilong Li, Niuniu Kong, Jie Zeng, Jiacheng Chen, Ke Ai   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Does Agricultural Science and Technological Innovation Always Boost Farmers’ Income? Evidence from China

Agriculture
Agricultural science and technological innovation (ASTI) provides important opportunities to enhance agricultural welfare. Based on comparative advantage, value chain, and resource dependence theories, this study employed a variety of econometric models,
Yi Xiang, Yuke Ding, Shaohua Yin
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Analysis of the Impact of Digital Inclusive Finance on the Development of Green Agriculture

Agronomy
Agricultural green development plays a crucial role in addressing the conflict between agricultural production and ecological environmental protection.
Zhuoya Ma, Zhentao Liu, Pan Zhang, Xue Wei, Wenhui Chen   +4 more
doaj   +1 more source

The acute effects of alcohol on auditory thresholds [PDF]

BMC Ear, Nose and Throat Disorders, 2007
There is very little knowledge about alcohol-induced hearing loss. Alcohol consumption and tolerance to loud noise is a well observed phenomenon as seen in the Western world where parties get noisier by the hour as the evening matures. This leads to increase in the referrals to the "hearing aid clinic" and the diagnosis of "cocktail party deafness ...
Upile, T, Sipaul, F, Jerjes, W, Singh, S, Nouraei, SA, El Maaytah, M, Andrews, P, Graham, J, Hopper, C, Wright, A   +9 more
openaire   +3 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Threshold Effect and Financial Intermediation in Economic Development [PDF]

This paper analyzes the theoretical finance-growth nexus. Using the Neoclassical growth framework, we raise a new issue where our finance-growth nexus has multiple stationary states with threshold effect.
Augier, Laurent, Soedarmono, Wahyoe
core  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source