Results 91 to 100 of about 11,447,501 (301)
Frontiers in Sustainable Food SystemsRevolutionary agricultural structural reforms in the supply chain and cutting-edge institutional mechanisms are pivotal in catalyzing a quantum leap in food production. China’s focus on achieving self-sufficiency in grain production for domestic security
Baozhong Cai +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
FoodsTea trees (Camellia sinensis) growing on selenium (Se)-rich soils often exhibit the phenomenon of cadmium (Cd) accumulation. However, the transport of Cd in the soil–tea tree–tea infusion continuum in such areas, as well as the impact of Se on Cd in this
Haizhong Wu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Evidence That There are Threshold Effects in Risk of Radiation. [PDF]
Journal of Nuclear Science and Technology, 1998 This review provides evidence that thresholds are observd in atomic bomb survivors for teratogenic and genetic effects of radiation and that for rodents subjected to radon gas and tritiated drinking water, radiation becomes non-carcinogenic at low dose-rates.
openaire +2 more sources
Threshold concept knowledge in analogue electronics: Support and assessment [PDF]
, 2012 In electrical engineering, as in other academic disciplines, there exist special, threshold concepts, where students often get stuck but which once grasped reveal new ways of thinking about a subject.
Scott, Jonathan B. +2 more
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Agricultural New-Quality Productive Forces and Carbon Efficiency: Empirical Evidence from China
AgricultureEnhancing agricultural carbon emission efficiency (ACEE) is a pivotal pathway for advancing environmentally sustainable transformation in agriculture and achieving the ‘dual carbon’ targets.
Liudi Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Effects of Parcellation and Threshold on Brain Connectivity Measures
PLOS ONE, 2019 Abstract It is shown that the statistical properties of connections between regions of the brain and their dependence on coarse-graining and thresholding in published data can be reproduced by a simple distance-based physical connectivity model.
T. C. Lacy, P. A. Robinson
openaire +4 more sources