Results 101 to 110 of about 1,468,325 (269)

Rapid expansion of small lakes in the permafrost zone of the Qinghai-Tibetan Plateau

International Journal of Digital Earth
Understanding the dynamics of small lakes (
Tao Yin, Xingxing Kuang, Sihai Liang, Ning Yuan, Yanan Su, Guoyu Wang, Li Wan   +6 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The Game Between Quality Induction and Traffic Constraint: A Non-Linear Threshold Study of Park Travel Carbon Emissions from an Urban–Rural Differentiation Perspective

Buildings
As global decarbonization strategies pivot towards the burgeoning sector of recreational mobility, the tension between the attractive force of high-quality amenities and the constraining capacity of transport infrastructure in urban parks has emerged as ...
He Zhang, Chao Wang, Hongjie Dong, Xiya Zhao, Yuxue Zhang, Mengge Du   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial differentiation and driving mechanisms of the Water-Energy-Food-Carbon coupling coordination degree in China

Shui kexue jinzhan
Dual Carbon Goals and resource constraints make it important to understand the evolutionary characteristics and driving mechanisms of the Water-Energy-Food-Carbon（WEFC） nexus. We propose a spatially adaptive coupling evaluation（SPACE） model that combines
Nan LIU, Baohui MEN, Xiaoyu HAN, Xiaolu XU, Xiaomeng YUAN, Hongrui WANG   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Agricultural New-Quality Productive Forces and Carbon Efficiency: Empirical Evidence from China

Agriculture
Enhancing agricultural carbon emission efficiency (ACEE) is a pivotal pathway for advancing environmentally sustainable transformation in agriculture and achieving the ‘dual carbon’ targets.
Liudi Li, Yuming Li, Bingbing Wei, Jing Zhang, Xiuguang Bai   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Trade-Offs or Synergy? Unraveling the Coupling Mechanisms and Critical Thresholds in the Food-Water-Land-Ecosystem Nexus

Land
Balancing ecological conservation with agricultural production in protected areas remains a critical challenge, particularly regarding the nexus of food, water, land, and ecosystems (FWLE).
Zheng Zuo, Li Tian, Haiqing Yang, Hui Zhao, Jing Wang, Lili Fan, Qirui Wang, Jinju Yang   +7 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source