Results 111 to 120 of about 11,447,501 (301)

Nonlinear Driving Forces and Threshold Effects: Land Use Function Trade-Offs in the Funiu Mountain Area from a Social-Ecological System Perspective

Land
A major obstacle to sustainable land management in ecologically sensitive areas is our limited understanding of the complex nonlinear mechanisms and threshold effects that dictate trade-offs between land use functions (LUFs).
Jie Yang, Boyan Zhou, Jiashuo Zhang, Shaoqi Pan, Jianhua Gao, Chenglin Qin   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Relationship between inflation and economic growth in Azerbaijani economy: is there any threshold effect? [PDF]

The study examines possibility of threshold effect of inflation on economic growth over the period of 2000-2009. Estimated threshold model indicates that there is a non-linear relationship between economic growth and inflation in the Azerbaijani economy ...
Hasanov, Fakhri
core  

The Game Between Quality Induction and Traffic Constraint: A Non-Linear Threshold Study of Park Travel Carbon Emissions from an Urban–Rural Differentiation Perspective

Buildings
As global decarbonization strategies pivot towards the burgeoning sector of recreational mobility, the tension between the attractive force of high-quality amenities and the constraining capacity of transport infrastructure in urban parks has emerged as ...
He Zhang, Chao Wang, Hongjie Dong, Xiya Zhao, Yuxue Zhang, Mengge Du   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Does a change in debt structure matter in earnings management? the application of nonlinear panel threshold test [PDF]

In this study, we apply Hansen¡¦s (1999) nonlinear panel threshold test, the most powerful test of its kind, to investigate the relationship between debt ratio and earnings management of 474 selected Taiwan-listed companies during the September 2002 ...
Yu-Shu Cheng, Yi-Pei Liu
core  

The role of core strength in front crawl performance: a qualitative analysis of expert coaches’ perspectives

Frontiers in Sports and Active Living
While core strength is theorized to be crucial for swimming performance, empirical evidence remains conflicting, and the perspectives of high-performance coaches—key stakeholders in training prescription-are largely unexplored.
Jinjin Dai, Junjun Xu, Zicheng Dai
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Full agreement and the provision of threshold public goods [PDF]

We report threshold public good experiments in which group members not only need to be individually willing to contribute enough to provide the public good but also have to agree with each other on what every group members should contribute.
Edward J. Cartwright, Federica Alberti
core  

Non-linear relationship between triglyceride glucose-body mass index and risk of diabetes in adults: a general population-based cohort study of Chinese adults using a publicly available DRYAD dataset

Frontiers in Endocrinology
ObjectiveDespite triglyceride glucose-body mass index (TyG-BMI) being a validated marker of insulin resistance, its prospective association with diabetes risk remains unclear; we therefore examined the impact of TyG-BMI on incident diabetes.MethodsThis ...
Shanshan Xiao, Chunyan Du, Nini Zhang, Xun Jiang, Tianxin Hu   +4 more
doaj   +1 more source