Results 121 to 130 of about 11,447,501 (301)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Does Digital Intelligence Technology Promote Integrated Innovation in the New Energy Industry? Evidence from China

Systems
The New Energy Industry (NEI) is a strategic sector for harmonizing the energy-economy-environment nexus, yet it faces challenges from high technological complexity and industrial fragmentation. DIT enables enterprises to transition from passive response
Zhibo Zhao, Zhe Huang, Yufei Qiao, Jiamin Ren   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial differentiation and driving mechanisms of the Water-Energy-Food-Carbon coupling coordination degree in China

Shui kexue jinzhan
Dual Carbon Goals and resource constraints make it important to understand the evolutionary characteristics and driving mechanisms of the Water-Energy-Food-Carbon（WEFC） nexus. We propose a spatially adaptive coupling evaluation（SPACE） model that combines
Nan LIU, Baohui MEN, Xiaoyu HAN, Xiaolu XU, Xiaomeng YUAN, Hongrui WANG   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Rapid expansion of small lakes in the permafrost zone of the Qinghai-Tibetan Plateau

International Journal of Digital Earth
Understanding the dynamics of small lakes (
Tao Yin, Xingxing Kuang, Sihai Liang, Ning Yuan, Yanan Su, Guoyu Wang, Li Wan   +6 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Threshold Autoregressive Model of Exchange Rate Pass through Effect: The Case of Croatia [PDF]

In this paper exchange rate pass-through effect in Croatia is estimated with nonlinear (asymmetric) threshold autoregressive model (TAR). In total 12285 regressions is estimated and a strong case of nonlinearity with single threshold is proven. According
Petra Posedel, Josip Tica
core  

Decannulation criteria in patients with acquired brain injury based on interval forced vital capacity monitoring: a prospective observational study

Frontiers in Neurology
ObjectiveOptimized decannulation timing in tracheostomized patients with acquired brain injury (ABI) remains a significant clinical challenge. We examined the association between the 3-week change in forced vital capacity (FVC) and time to successful ...
Yunhong Deng, Yunhong Deng, Fuqiang Wang, Yaojiang Li, Jinfeng Liang, Hanbo Chen, Wenying Xie, Bizhou Fu, Man Hao   +8 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source