Results 121 to 130 of about 12,065,388 (305)

Non-linear relationship between triglyceride glucose-body mass index and risk of diabetes in adults: a general population-based cohort study of Chinese adults using a publicly available DRYAD dataset

Frontiers in Endocrinology
ObjectiveDespite triglyceride glucose-body mass index (TyG-BMI) being a validated marker of insulin resistance, its prospective association with diabetes risk remains unclear; we therefore examined the impact of TyG-BMI on incident diabetes.MethodsThis ...
Shanshan Xiao, Chunyan Du, Nini Zhang, Xun Jiang, Tianxin Hu   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Does Digital Intelligence Technology Promote Integrated Innovation in the New Energy Industry? Evidence from China

Systems
The New Energy Industry (NEI) is a strategic sector for harmonizing the energy-economy-environment nexus, yet it faces challenges from high technological complexity and industrial fragmentation. DIT enables enterprises to transition from passive response
Zhibo Zhao, Zhe Huang, Yufei Qiao, Jiamin Ren   +3 more
doaj   +1 more source

Threshold signatures from VOLE

, 2023
reservedThe focus of this thesis is on threshold digital signatures and in particular on Schnorr signatures (1991). Following the expiration of its patent in 2008, Schnorr signature has gained significance in the realm of digital signatures due to its ...
MARCHIORO, ALESSANDRO
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Nonlinear Driving Forces and Threshold Effects: Land Use Function Trade-Offs in the Funiu Mountain Area from a Social-Ecological System Perspective

Land
A major obstacle to sustainable land management in ecologically sensitive areas is our limited understanding of the complex nonlinear mechanisms and threshold effects that dictate trade-offs between land use functions (LUFs).
Jie Yang, Boyan Zhou, Jiashuo Zhang, Shaoqi Pan, Jianhua Gao, Chenglin Qin   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Game Between Quality Induction and Traffic Constraint: A Non-Linear Threshold Study of Park Travel Carbon Emissions from an Urban–Rural Differentiation Perspective

Buildings
As global decarbonization strategies pivot towards the burgeoning sector of recreational mobility, the tension between the attractive force of high-quality amenities and the constraining capacity of transport infrastructure in urban parks has emerged as ...
He Zhang, Chao Wang, Hongjie Dong, Xiya Zhao, Yuxue Zhang, Mengge Du   +5 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source