Results 141 to 150 of about 11,225,904 (309)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Nonlinear and Spatial Effects of Housing Prices on Urban–Rural Income Inequality: Evidence from Dynamic Spatial Threshold Models in Mainland China

Mathematics
This study investigates how housing prices influence urban–rural income inequality (URG) in mainland China by explicitly incorporating spatial interdependence and nonlinear adjustment mechanisms, features often neglected in previous research.
Mingyang Li, Woraphon Yamaka, Paravee Maneejuk   +2 more
doaj   +1 more source

Sustainable effects of a low-threshold physical activity intervention on health-related quality of life in residential aged care

, 2014
Viktoria Quehenberger, Martin Cichocki, Karl Krajic Health promoting Long term Care, Ludwig Boltzmann Institut Health Promotion Research, Vienna, Austria Background: Mobility is a main issue for health-related quality of life in old age.
Quehenberger V, Krajic K, Cichocki M
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The impact and transmission mechanism of environmental regulation on green total factor productivity in the Yangtze River Economic Belt

Frontiers in Environmental Science
Against the strategic backdrop of prioritizing ecological conservation and pursuing green development in the Yangtze River Economic Belt (YREB), balancing economic growth with environmental protection is critical for sustainable development.
Ruisi Zhang, Yaqi Wu, Jie Fang, Jinhua Cheng, Jinhua Cheng, Lu Chen, Long Li, Keying Wang   +7 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Interpretable Nonlinear Forecasting of China’s CPI with Adaptive Threshold ARMA and Information Criterion Guided Integration

Big Data and Cognitive Computing
Accurate forecasting of China’s Consumer Price Index (CPI) is crucial for effective macroeconomic policymaking, yet remains challenging due to structural breaks and nonlinear dynamics inherent in the inflation process.
Dezhi Cao, Yue Zhao, Xiaona Xu
doaj   +1 more source

The reality about aid and governance: the threshold theory [PDF]

The aim of this survey is to explain the real impact of aid on governance in the developing countries: including the subsahara and the MENA region during the period 1990-2004 by using the “threshold theory”.
Jaouadi, Saïd
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source