Results 121 to 130 of about 11,225,904 (309)

Threshold concept knowledge in analogue electronics: Support and assessment [PDF]

open access: yes, 2012
In electrical engineering, as in other academic disciplines, there exist special, threshold concepts, where students often get stuck but which once grasped reveal new ways of thinking about a subject.
Scott, Jonathan B.   +2 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Are House Prices Characterized by Threshold Effects? Evidence from Developed and Post-Transition Countries [PDF]

open access: yes
The authors use a nonlinear framework in order to explore house price determinants and adjustment properties. They test for threshold cointegration using a sample of four developed countries (the United States, the United Kingdom, Spain, and Ireland) and
Petra Posedel, Maruška Vizek
core  

Using threshold messages to promote physical activity: Implications for public perceptions of health effects

open access: yes, 2014
Background: The promotion of physical activity (PA) guidelines to the general public is an important issue that lacks empirical investigation. PA campaigns often feature participation thresholds that cite PA guidelines verbatim [e.g.
Knox, Emily C. L.   +4 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Searching Threshold Inflation for India [PDF]

open access: yes
The present study is an effort to examine econometrically the presence of threshold level of inflation for India, in an environment where expected inflation is in double digit.
Prakash Singh
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Foreign direct investment and green GDP: the thresholds of financial development for economic policies

open access: yesCogent Economics & Finance
This study aims to examine the impact of foreign direct investment (FDI) on green GDP while analyzing the role of financial development thresholds in moderating the relationship in the ASEAN-6 countries.
Ngoc Toan Bui, Thu-Trang Thi Doan
doaj   +1 more source

THRESHOLD MODELS IN THEORY AND PRACTICE [PDF]

open access: yes
Threshold models have gained much recent attention in applied economics for modeling nonlinear behavior. The appeal for these models is due in part to the observable pattern that many economic variables follow, such as asymmetric adjustment towards ...
Gauthier, Wayne M., Zapata, Hector O.
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Home - About - Disclaimer - Privacy