Results 101 to 110 of about 11,225,904 (309)

Digitalization, E-Commerce Capability, and Firm Value in GCC Countries: Evidence from a Panel Threshold Model

Economies
This study examines the relationship between digitalization, e-commerce capability, and firm value in Gulf Cooperation Council (GCC) countries. Using an unbalanced panel of 200 non-financial firms over the period of 2015–2024, the analysis employs a ...
Noura Ben Mbarek
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Unveiling the cooling effects of urban green spaces in Eastern China: spatial heterogeneity, diurnal asymmetry, and nonlinear margins of 2D/3D features

GIScience & Remote Sensing
Urban green spaces (UGS) play an important role in mitigating urban heat island effects. However, the mechanisms underlying their cooling effects are still not fully understood, particularly regarding the role of three-dimensional vegetation structure ...
Huaiqing Wang, Chaobin Yang, Weiqi Zhou, Chao Wang, Lifeng Liu   +4 more
doaj   +1 more source

Testing for threshold effects in regression models [PDF]

In this article, we develop a general method for testing threshold effects in regression models, using sup-likelihood-ratio (LR)-type statistics. Although the sup-LR-type test statistic has been considered in the literature, our method for establishing ...
Myung Hwan Seo, Sokbae 'Simon' Lee, Youngki Shin   +2 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

How the digital economy enhances the grain supply chain resilience in China: exploring the moderating effects of government innovation-driven

Frontiers in Sustainable Food Systems
IntroductionEnsuring food security in the new development paradigm urgently requires increasing the grain supply chain resilience. In order to clarify how can significantly enhance grain supply chain resilience, to demonstrate the relationship between ...
Jinrui Chang, Huiming Jiang, Jianbo Liu, Mingyang Li   +3 more
doaj   +1 more source

Threshold concepts and introductory electronics [PDF]

, 2010
Electronics and circuit theory are acknowledged as troublesome subjects when first introduced to students. This leads to low student retention into later electronics courses, especially in universities that offer a common first year where students are
Scott, Jonathan B., Cowie, Bronwen, Peter, Mira, Harlow, Ann   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Economic Optimization of Bike-Sharing Systems via Nonlinear Threshold Effects: An Interpretable Machine Learning Approach in Xi’an, China

ISPRS International Journal of Geo-Information
As bike-sharing systems become increasingly integral to sustainable urban mobility, understanding their economic viability requires moving beyond conventional linear models to capture complex operational dynamics.
Haolong Yang, Chen Feng, Chao Gao
doaj   +1 more source

Considering threshold effects in the long-run equilibrium in a vector error correction model: An application to the German apple market [PDF]

We propose a three-step procedure to estimate a regime-dependent vector error correction model (VECM). In this model, not only the short-run adjustment process towards equilibrium is non-linear, as in threshold VECM and Markov switching VECM frameworks ...
von Cramon-Taubadel, Stephan, Goetz, Linde   +1 more
core