Results 81 to 90 of about 11,225,904 (309)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
LandThe impact of the built environment (BE) on urban vitality (UV) has become a key issue in the field of urban planning. However, few studies have explored the impact of the BE on UV from the perspective of urban function zones (UFZs).
Fengshuo Sun, Enxu Wang
doaj +1 more source
Développement Durable et Territoires, 2004 This article seeks to specify the place of various dimensions of sustainable development within development economics, in particular human and social dimensions.
Bruno Boidin
doaj +1 more source
"Threshold Effects in the U.S. Budget Deficit" [PDF]
We contribute to the debate on whether the large U.S. federal budget deficits are sustainable in the long run. We model the U.S. government deficit per capita as a threshold autoregressive process. We find evidence that the U.S.
Andrea Cipollini +2 more
core
Threshold signatures from VOLE
, 2023 reservedThe focus of this thesis is on threshold digital signatures and in particular on Schnorr signatures (1991). Following the expiration of its patent in 2008, Schnorr signature has gained significance in the realm of digital signatures due to its ...
MARCHIORO, ALESSANDRO
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Research on the impact and mechanism of green credit on carbon emissions
Frontiers in SustainabilityThis paper examines the relationship between green credit and carbon emissions using balanced provincial panel data from China (2012–2024). A two-way fixed effects model serves as the baseline framework, with mediation and threshold analyses exploring ...
Zhao Chen +2 more
doaj +1 more source
Threshold Effects in Cigarette Addiction: An Application of the Threshold Model in Dynamic Panels [PDF]
We adopt the threshold model of myopic cigarette addiction to US state-level panel data. The threshold model is used to identify the structural effects of cigarette demand determinants across the income stratification.
Yi-Chi Chen, Chang-Ching Lin
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Natural Disasters and Development Thresholds: Infrastructure, Nonlinearity, and Economic Resilience
SystemsNatural disasters pose major challenges to economic development, yet empirical evidence on their growth effects remains mixed. This study examines whether the macroeconomic impact of disasters depends on infrastructure development, using electricity ...
Keisuke Kokubun
doaj +1 more source