Results 121 to 130 of about 452,379 (303)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Assessment of some Hematological and Biochemical Changes Among Workers Exposed to Liquified Natural Gas in Egypt

Journal of High Institute of Public Health
Background: Natural gas (NG) is one of the world’s three primary energy sources. However, workers in the liquefied natural gas (LNG) industry are routinely exposed to various occupational hazards, including mechanical, physical, chemical, and ...
Emad F. Rizk, Hassan A. Othman, Ragaa M. Elgazzar, Zeinab M. Badreldeen   +3 more
doaj   +1 more source

Extreme Value Analysis of Solar Green‐Line Corona During the Time Interval 1939–2025

Space Weather
Predicting the probability of extreme solar events is critical to understanding how to mitigate risks associated with space weather disasters, as their occurrence can pose a threat to life and infrastructure on Earth or in near‐Earth orbit.
Miao Wan, Linhua Deng, Tingting Xu, Ruoxue Sha, Yuanyong Liu, Wenhao Cui, Qianrui Wu   +6 more
doaj   +1 more source

An M-Estimator for Tail Dependence in Arbitrary Dimensions

Consider a random sample in the max-domain of attraction of a multivariate extreme value distribution such that the dependence structure of the attractor belongs to a parametric model.
Krajina, A., Segers, J., Einmahl, J.H.J.
core   +1 more source

Biohazards: standards, guidelines, and proposals for threshold limit values

, 2004
Ekspozycja na czynniki biologiczne często prowadzi do wystąpienia wielu niekorzystnych skutków zdrowotnych u narażonych osób. Wypracowanie wartości normatywnych i (lub) referencyjnych dla biologicznych czynników szkodliwych obecnych w powietrzu jest ...
Górny, R. L.
core  

Environmental surveillance monitoring XYZ-La Crosse [PDF]

, 2001
Plan BThere are variety of chemicals in the workplace. These variety of chemicals present variety of hazards. The primary purpose of monitoring air in the work environment is to determine the level of employees exposure to airborne contaminants and to ...
Gono, Charles Saye
core  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source