Results 121 to 130 of about 3,798,889 (297)

Comparison of approximation methods for genomic estimated breeding values from observed to liability scales in dairy cattle health traits

Journal of Dairy Science
: The GEBV for health traits are typically published as probabilities obtained using threshold models. While these models benefit from theoretical properties, they require substantial computational resources and may face convergence issues. Linear models
Denyus Augusto de Oliveira Padilha, Daniela Lourenco, Daniel Gianola, Fernando Bussiman, Ignacy Misztal, Hélène Wilmot, Dianelys González-Peña, Giovana Vargas, Gerson A. Oliveira, Jr., Miguel A. Sánchez-Castro, Natascha Vukasinovic, Jorge Hidalgo   +11 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

State-Dependent Threshold STAR Models [PDF]

, 2010
JEL Classification: C22 ...
Michael J. Dueker, Zacharias Psaradakis, Martin Sola, Fabio Spagnolo   +3 more
openaire   +2 more sources

A discrete-time performance model for congestion control mechanism using queue thresholds with QOS constraints [PDF]

, 2005
This paper presents a new analytical framework for the congestion control of Internet traffic using a queue threshold scheme. This framework includes two discrete-time analytical models for the performance evaluation of a threshold based congestion ...
Awan, Irfan U., Guan, Lin, Woodward, Mike E.   +2 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Research on the Impact of the Digital Economy and Technological Innovation on Agricultural Carbon Emissions

Land
The digital economy, closely linked to agricultural progress, plays a key role in reducing agricultural carbon emissions. By utilizing panel data between 2011 and 2021 from 30 Chinese provincial-level regions, the present work empirically assesses the ...
Jian Li, Xiangchen Sheng, Shuhua Zhang, Yixuan Wang   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Salinity threshold for phosphorus limitation in an estuary-coast continuum

Frontiers in Marine Science
River-derived nutrient imbalances can induce phosphorus (P) limitation in coastal plankton, but the salinity thresholds that govern this phenomenon have received little attention.
Shujie Cai, Weiran Liu, Zhuyin Tong, Lizhen Lin, Linjian Ou, Wupeng Xiao, Bangqin Huang   +6 more
doaj   +1 more source