Results 31 to 40 of about 754,428 (266)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Obtaining Thresholds for the Effectiveness of Business Process Mining [PDF]

2011 International Symposium on Empirical Software Engineering and Measurement, 2011
Business process mining is a powerful tool to retrieve the valuable business knowledge embedded in existing information systems. The effectiveness of this kind of proposal is usually evaluated using recall and precision, which respectively measure the completeness and exactness of the retrieved business processes.
Ricardo Pérez-Castillo, Laura Sánchez-González, Mario Piattini, Félix García 0001, Ignacio García Rodríguez de Guzmán   +4 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Comparing background elimination approaches for processing of ancient Thai manuscipts on palm leaves

, 2009
The objective of the Preservation of Palm Leaf Manuscripts Project at Mahasarakham University at Thailand is to preserve and retrieve traditional knowledge from ancient manuscripts recorded on palm leaves. An essential task in the process is to recognize
Fung, C.C., Chun Che Fung, Rapeeporn Chamchong, Chamchong, R.   +3 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Photoionization processes in NO in the threshold region

Chemical Physics Letters, 1997
The photoion excitation spectrum of NO has been measured in the 9.26-13.8 eV region using synchrotron light and the isotopic targets 14N160, 15N160 and 15N180.
P. Erman, A. Karawajczyk, E. Rachlew-Källne, M. Stankiewicz, K. Yoshiki Franzén, P. Sannes, L. Veseth   +6 more
openaire   +3 more sources

Accent processing in dementia. [PDF]

, 2012
Accented speech conveys important nonverbal information about the speaker as well as presenting the brain with the problem of decoding a non-canonical auditory signal.
Hailstone, Julia C, Ridgway, Gerard R, Bartlett, Jonathan W, Warren, Jason D, Crutch, Sebastian J, Bartlett, Jonathan W., Ridgway, Gerard R., Hailstone, Julia C., Warren, Jason D., Goll, Johanna C, Crutch, Sebastian J., Goll, Johanna C.   +11 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source