Results 61 to 70 of about 250,897 (267)

Accelerated Projected Gradient Method for Linear Inverse Problems with Sparsity Constraints

, 2008
Regularization of ill-posed linear inverse problems via $\ell_1$ penalization has been proposed for cases where the solution is known to be (almost) sparse. One way to obtain the minimizer of such an $\ell_1$ penalized functional is via an iterative soft-
A. Chambolle, A. Cohen, A. Cohen, A. Cohen, A. Cohen, B. Efron, C. Canuto, D.L. Donoho, D.L. Donoho, D.L. Donoho, D.L. Donoho, D.L. Donoho, D.L. Donoho, E. Candès, E.J. Candès, E.J. Candès, E.J. Candès, G. Teschke, H. Rauhut, H.W. Engl, I. Daubechies, I. Daubechies, I. Daubechies, I. Loris, Ignace Loris, Ingrid Daubechies, J.-L. Starck, J.-L. Starck, L.M. Brègman, M. Fornasier, M. Fornasier, M. Fornasier, M. Fornasier, M.A.T. Figueiredo, M.A.T. Figueiredo, Massimo Fornasier, O. Christensen, P.L. Combettes, R. Ramlau, S. Dahlke, S. Dahlke, S. Dahlke, S. Mallat, S. Wolfram, Y.I. Alber   +44 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Determination of Colles fracture risk index by X-ray images with the computer vision application

Bolʹ, Sustavy, Pozvonočnik
Background. Modelling a predictive risk index for Colles fractures using X-ray image analysis is a crucial application in orthopaedics since these fractures have essential health and economic burdens, particularly among the elderly. Previous research has
Wisam A. Hussein, Hussain J. AlKhatteib, Jawad K. Abbas   +2 more
doaj   +1 more source

Wavelet-based denoising by customized thresholding [PDF]

, 2004
The problem of estimating a signal that is corrupted by additive noise has been of interest to many researchers for practical as well as theoretical reasons.
Vaidyanathan, P. P., Yoon, Byung-Jun
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Thresholding approaches for estimating paraspinal muscle fat infiltration using T1‐ and T2‐weighted MRI: Comparative analysis using water–fat MRI

JOR Spine
Background Paraspinal muscle fat infiltration is associated with spinal degeneration and low back pain, however, quantifying muscle fat using clinical magnetic resonance imaging (MRI) techniques continues to be a challenge.
Jessica Ornowski, Lucas Dziesinski, Madeline Hess, Roland Krug, Maryse Fortin, Abel Torres‐Espin, Sharmila Majumdar, Valentina Pedoia, Noah B. Bonnheim, Jeannie F. Bailey   +9 more
doaj   +1 more source