Results 81 to 90 of about 253,991 (289)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Sparse image reconstruction for molecular imaging

open access: yes, 2008
The application that motivates this paper is molecular imaging at the atomic level. When discretized at sub-atomic distances, the volume is inherently sparse.
Hero III, Alfred O.   +2 more
core   +1 more source

Threefold thresholds

open access: yesmanuscripta mathematica, 2004
33 pages ...
McKernan, James, Prokhorov, Yuri
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

An Overview of Segmentation Algorithms for the Analysis of Anomalies on Medical Images

open access: yesJournal of Intelligent Systems, 2018
Human disease identification from the scanned body parts helps medical practitioners make the right decision in lesser time. Image segmentation plays a vital role in automated diagnosis for the delineation of anatomical organs and anomalies.
Kumar Subbiahpillai Neelakantapillai   +2 more
doaj   +1 more source

Sparse Solution of Underdetermined Linear Equations via Adaptively Iterative Thresholding [PDF]

open access: yes, 2013
Finding the sparset solution of an underdetermined system of linear equations $y=Ax$ has attracted considerable attention in recent years. Among a large number of algorithms, iterative thresholding algorithms are recognized as one of the most efficient ...
Lin, Shaobo, Xu, Zongben, Zeng, Jinshan
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Global Thresholding and Multiple Pass Parsing

open access: yes, 1997
We present a variation on classic beam thresholding techniques that is up to an order of magnitude faster than the traditional method, at the same performance level.
Goodman, Joshua
core   +2 more sources

Rainbow Thresholds

open access: yesSIAM Journal on Discrete Mathematics
We extend a recent breakthrough result relating expectation thresholds and actual thresholds to include some rainbow versions.
Tolson Bell   +2 more
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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