Results 101 to 110 of about 137,983 (312)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Thresholding RULES and iterative shrinkage/thresholding algorithm: A convergence study
, 2014 International audienceImaging inverse problems can be formulated as an optimization problem and solved thanks to algorithms such as forward-backward or ISTA (Iterative Shrinkage/Thresholding Algorithm) for which non smooth functionals with sparsity ...
Matthieu Kowalski, Kowalski, Matthieu
core +1 more source
Intensity estimation of non-homogeneous Poisson processes from shifted trajectories [PDF]
, 2013 In this paper, we consider the problem of estimating nonparametrically a mean pattern intensity λ from the observation of n independent and non-homogeneous Poisson processes N1,…,Nn on the interval [0,1].
Marteau, Clément +3 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Thresholding Estimators for Linear Inverse Problems and Deconvolutions
, 2003 Thresholding algorithms in an orthonormal basis are studied to estimate noisy discrete signals degraded by a linear operator whose inverse is not bounded.
Deconvolutions +3 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
On the Threshold of a Dream* [PDF]
Critical Care Medicine, 2015 Standard work for sepsis employing a bundled treatment approach emphasizes the need to keep an eye on the clock (1). Like trauma, there also exists a ‘golden hour’ for sepsis resuscitation (2). Accordingly time to initial fluid administration (3, 4) and time to administration of appropriate antimicrobials (5, 6) represent key elements of early sepsis ...
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source