Results 31 to 40 of about 321,697 (294)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The effect of social network diversity and social support on the thriving of healthcare workers

Acta Medica Alanya, 2022
Aim: The well-being of healthcare workers is a critical indicator in the provision of high-quality care. Although researchers have stressed the importance of social interactions and social support, scarce data exist about their effects on healthcare ...
Kemal Kuşçu, Ozge Pasin, Merve Yalçınay -inan, Esra Bilir, Ozge Kılıc   +4 more
doaj   +1 more source

The Microbial State: Global Thriving and the Body Politic by Stefanie R. Fishel [PDF]

, 2018
Review of Stefanie R.
Purvis, Dustin
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Global Human Thriving: A Christian Perspective [PDF]

, 2009
(excerpt) Talking about global human thriving from a decidedly religious point of view requires interpreting a particular religious tradition in light of today’s ubiquitous ecological, economic, and political challenges.
Grundmann, Christoffer H.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Ensuring Optimal Outcomes for Preterm Infants after NICU Discharge: A Life Course Health Development Approach to High-Risk Infant Follow-Up

Children
Children born prematurely (
Jonathan S. Litt, Neal Halfon, Michael E. Msall, Shirley Ann Russ, Susan R. Hintz   +4 more
doaj   +1 more source

Workplace Belonging of Women Healthcare Professionals Relates to Likelihood of Leaving

Journal of Healthcare Leadership, 2023
Judith D Schaechter,1,2 Richard Goldstein,1 Ross D Zafonte,1– 4 Julie K Silver1– 4 1Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA; 2Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation
Schaechter JD, Goldstein R, Zafonte RD, Silver JK   +3 more
doaj  

Surviving, and Maybe Thriving, on Vouchers [PDF]

, 2000
The Workforce Investment Act (WIA), the new law restructuring the nation's workforce development system, marks a significant change for job seekers and the practitioners who serve them.
Sheila Maguire
core