Results 31 to 40 of about 48,404 (190)

SECONDARY TEACHING THRIVING: INVESTIGATING SECONDARY TEACHER WELL-BEING AND CONTRIBUTING FACTORS TO THRIVING [PDF]

, 2023
The purpose of this study was to examine secondary teacher thriving using the PERMA well-being model. This non-experimental, quantitative survey aimed to discover secondary teachers’ well-being and how the dimensions of well-being are predictive of ...
Nichols, Ryan H.
core  

Leader Inclusiveness and Taking Charge: The Role of Thriving at Work and Regulatory Focus

Frontiers in Psychology, 2019
Based on self-determination theory, this study developed and tested a moderated mediation model to explore the effect of leader inclusiveness on employee taking charge behavior in addition to the mediating role of thriving at work and the moderating role
Nan Li, Qiu-Yun Guo, Qiu-Yun Guo, Hua Wan   +3 more
doaj   +1 more source

A protocol for tracking scholarly output to evaluate the impact of the RADx-UP program on community-engaged COVID-19 research

Journal of Clinical and Translational Science
Introduction: Portfolio-level publication tracking collects research output from related programs. Tracking publications is imperative to evaluate the scholarly impact of a program, synthesize program findings, and document impact to funders.
Valerie A. Lucas, Marlena L. Kuhn, Kristen D. Witkemper, Tara Carr, Abisola Osinuga Snipes, Barrie E. Hayes, Michelle Song, Leah Frerichs, Gaurav Dave   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The breakthrough discoveries for thriving with bipolar disorder (BD2) integrated network longitudinal cohort protocol

International Journal of Bipolar Disorders
Bipolar Disorder (BD) is a highly complex and heterogeneous disorder. As such, accurate diagnosis is often delayed, and effective treatment options are limited.
Emily G. Baxi, Megan Shanahan, Daniel L. Pham, Veronica C. Beck, Kelsey M. Barcomb, Eric J. Nestler, Mark A. Frye, Cara M. Altimus, Katherine E. Burdick   +8 more
doaj   +1 more source

The civic engagement community participation thriving model: A multi-faceted thriving model to promote socially excluded young adult women

Frontiers in Psychology, 2022
Social policies to promote socially excluded young adult women generally concentrate on education, employment, and residence but tend to neglect thriving. The current article puts forward a Civic Engagement Community Participation Thriving Model (CECP-TM)
Irit Birger Sagiv, Limor Goldner, Yifat Carmel, Yifat Carmel   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Ethical criteria for self-identifying societal risk associated with dangerous gain-of-function research

mSphere
The 5 May 2025 executive order (EO) “Improving the safety and security of biological research” established a federal funding pause for dangerous gain-of-function (DGoF) research, defined as seeking certain experimental outcomes and deemed capable of ...
Patricia Delarosa, C. Matthew Sharkey, Kristjan Hollo   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source