Results 91 to 100 of about 5,734 (191)

Milli-spinner thrombectomy

Nature
Abstract Blockage of blood flow in arteries or veins by blood clots can lead to serious medical conditions. Mechanical thrombectomy (MT), minimally invasive endovascular procedures that utilize aspiration, stent retriever, or cutting mechanisms for clot removal have emerged as an effective treatment modality for ischemic stroke, myocardial ...
Ruike Renee Zhao, Yilong Chang, Qi Li, Shuai Wu, Benjamin Pulli, Darren Salmi, Paul Yock, Jeremy Heit   +7 more
openaire   +2 more sources

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, Volume 15, Issue 38, 16 October 2026.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Surgical Thrombectomy

Clinical and Applied Thrombosis/Hemostasis, 2013
A. Nicolaides, J. Fareed, A. K. Kakkar, A. J. Comerota, S. Z. Goldhaber, R. Hull, K. Myers, M. Samama, J. Fletcher, E. Kalodiki, D. Bergqvist, J. Bonnar, J. A. Caprini, C. Carter, J. Conard, B. Eklof, I. Elalamy, G. Gerotziafas, G. Geroulakos, A. Giannoukas, I. Greer, M. Griffin, S. Kakkos, M. R. Lassen, G. D. O. Lowe, A. Markel, P. Prandoni, G. Raskob, A. C. Spyropoulos, A. G. Turpie, J. M. Walenga, D. Warwick   +31 more
openaire   +2 more sources

Tenecteplase for Thrombectomy Thrombolysis [PDF]

Neurosurgery, 2018
Robert M Starke, David McCarthy, Ricardo J Komotar, E Sander Connolly   +3 more
openaire   +2 more sources

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, Volume 13, Issue 56, 9 October 2026.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, Volume 13, Issue 59, 23 October 2026.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

The evolution of personalized stroke thrombectomy

Frontiers in Surgery
Stroke is a leading cause of disability and death worldwide, with acute ischemic stroke accounting for most cases. Mechanical thrombectomy is a widely accepted treatment modality in appropriately selected patients, demonstrating improved functional ...
Emmanuel O. Mensah, Yew-Weng Fong, Yew-Weng Fong, Sandeep Muram, Christopher S. Ogilvy, Philipp Taussky   +5 more
doaj   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, Volume 100, Issue 4, Page 824-840, October 2026.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Endovascular Thrombectomy in Cancer‐Related Stroke: Comparison of Thrombectomy Methods

Stroke: Vascular and Interventional Neurology
BACKGROUND The optimal first‐line device choice for endovascular treatment (EVT) of cancer‐related stroke remains largely unknown. In this study, we evaluated the efficacy and safety of the EVT methods for treating cancer‐related stroke thrombi. METHODS
Jaeseob Yun, Kwang Hyun Kim, Solbi Kim, Kyu Seon Chung, Hyo Suk Nam, Ji Hoe Heo, Byung Moon Kim, Young Dae Kim, Dong Joon Kim   +8 more
openaire   +3 more sources