Results 131 to 140 of about 68,330 (260)

Restricting Synaptotagmin‐3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re‐Programming

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Restriction of Syt3 internalization by peptide 3Y conferred robust neuroprotection against cerebral ischemia/reperfusion injury. Mechanistically, 3Y suppressed neuronal apoptosis fundamentally, and additionally, these salvaged neurons orchestrated and remodulated the transformation of surrounding microglia toward an anti‐inflammatory and ...
Hua Xu, Hongbo Mi, Rong Cheng, Tiantian Gui, Fangzhou Hu, Yi Yang, Jian Cheng, Qun Xue   +7 more
wiley   +1 more source

Timing of vessel imaging for suspected large vessel occlusions does not affect groin puncture time in transfer patients with stroke. [PDF]

, 2018
BACKGROUND: Access to endovascular therapy (ET) in cases of acute ischemic stroke may be limited, and rapid transfer of eligible patients to hospitals with endovascular capability is needed.
Dhamoon, Mandip S., Fifi, Johanna T., Liang, John W., Stein, Laura, Tuhrim, Stanley, Wilson, Natalie   +5 more
core   +1 more source

Crossing communicating artery thrombectomy for acute ischemic stroke patients with multiple vessels occlusion

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Acute ischemic stroke with multiple large vessel occlusions was usually noted in unilateral internal carotid artery region or vertebrobasilar artery region, whereas some rare cases could present multiple circulatory system vessel occlusions. For patients
Xuan Zhu, Fang Shen, Hongjian Shen, Minmin Zhang, Pengfei Xing, Yongwei Zhang, Jianmin Liu   +6 more
doaj   +1 more source

IL‐17A Promotes NETs Formation via the PKCζ–ERK–ROS–PAD4 Pathway in a Mouse Model of Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Our study demonstrates that IL‐17A promotes NET formation by upregulating PAD4 through the PKCζ–ERK–ROS pathway, thereby exacerbating ischemic brain injury. IL‐17A regulates NET formation through this newly identified molecular pathway, and targeting this pathway may offer a novel therapeutic strategy for stroke.
Chang Liu, Qi Chen, Weijia Chen, Xinyue Han, Xiaowen Qiao, Jun Guo, Wei Su, Qingqing Dai   +7 more
wiley   +1 more source

Antiphosphatidylserine antibody as a cause of multiple dural venous sinus thromboses and ST-elevation myocardial infarction [PDF]

, 2018
Objective: Rare disease Background: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antibodies directed against phos-pholipids on plasma membranes. Through unclear mechanisms, APS confers hypercoagulability.
Marquardt, Caillin W., Pickens, Peter V., Varner, Chelsea K.   +2 more
core   +1 more source

Pan‐Immune‐Inflammation Value for Mortality Risk Stratification in Critically Ill Patients With Acute Ischemic Stroke: A Cohort Study Based on the MIMIC‐IV Database

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
This study identified a nonlinear, reverse L‐shaped relationship between the pan‐immune‐inflammation value (PIV) and all‐cause mortality (ACM) in critically ill acute ischemic stroke (AIS) patients, with a distinct threshold for risk stratification. Furthermore, the prognostic value of PIV was significantly stronger in patients without sepsis.
Zhenzhu Li
wiley   +1 more source

Orthotopic liver transplantation in U.S. veterans under primary tacrolimus immunosupression. [PDF]

, 1996
The evolution and refinement of surgical techniques, per ioperative patient care, and immunosuppression hav~ estab~ished orthoto~ic li~er transplantation (OLTX) as a ~ighly successful therapeutic modality for patients wrth end-stage hver disease.
Doyle, HR, Fung, JJ, Gayowski, T, Marino, IR, Singh, N, Starzl, TE, Todo, S, Wagener, MM   +7 more
core  

Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis in Rats After Stroke by Activating the NRF2/GPX4/SLC7A11 Pathway

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Traditional Chinese herbal formula XuMingZhuSan showed its efficacy in treating stroke. It was capable of attenuating neuronal damage and mitochondrial damage and reducing infarction volume in rats with stroke. Mechanically, XuMingZhuSan might treat stroke by relieving neuronal ferroptosis via activating the NRF2/GPX4/SLC7A11 pathway.
Xi Liu, Cheng Wang, Ling Han, Yian Xiao, Hanchang Yu, Zhongxu Hu, Xiyun Fei, Min Peng, Jilin Zhou, Zhijun Zhong   +9 more
wiley   +1 more source

Breaking the 12-hour barrier: A case report on stent-retriever mechanical thrombectomy in a late-presenting acute ischemic stroke

Radiology Case Reports
Ischemic stroke remains a leading health concern globally, particularly in high-challenge terrains such as Indonesia. Mechanical thrombectomy is one of the main surgical approaches for acute ischemic stroke, and it has significant benefits for patients ...
Jacub Pandelaki, MD, PhD, Krishna Pandu Wicaksono, MD, PhD, Heltara Ramandika, MD, Dessy Natalia Purba, MD, Rizkya Amelia, MD, Olivia Ardini, MD, Jason, MD   +6 more
doaj   +1 more source

The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
Both transient ischaemic attack (TIA) and ischaemic stroke lead to an increase in individual cellular‐derived populations of extracellular vesicles (EVs), including endothelial, platelet and leukocyte derived. These EVs have downstream roles in the pathophysiological events associated with TIA and stroke, including dysregulated inflammation and ...
Rebecca Marie Raven, Philip Eurig James, Keith Morris, Jessica Olivia Williams   +3 more
wiley   +1 more source