Results 141 to 150 of about 51,793 (265)

Neuroprotective Effects of Phenothiazines on Acute Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
For acute ischemic stroke due to large vessel occlusion, adjunctive neuroprotective therapy with mechanical thrombectomy is important; however, current treatment options are relatively limited. Phenothiazines such as chlorpromazine and promethazine (C + P) have shown potential neuroprotective effects in preclinical studies.
Qi Wang, Weili Li, Di Wu, Shuaili Xu, Xunming Ji   +4 more
wiley   +1 more source

Endovascular Thrombectomy in Cancer‐Related Stroke: Comparison of Thrombectomy Methods

Stroke: Vascular and Interventional Neurology
BACKGROUND The optimal first‐line device choice for endovascular treatment (EVT) of cancer‐related stroke remains largely unknown. In this study, we evaluated the efficacy and safety of the EVT methods for treating cancer‐related stroke thrombi. METHODS
Jaeseob Yun, Kwang Hyun Kim, Solbi Kim, Kyu Seon Chung, Hyo Suk Nam, Ji Hoe Heo, Byung Moon Kim, Young Dae Kim, Dong Joon Kim   +8 more
openaire   +3 more sources

Where Evidence‐Based Medicine Meets AI: Promise, Pitfalls, and Practice

AEM Education and Training, Volume 10, Issue 3, June 2026.
Sangil Lee, Joshua Davis, Ken Milne, Christina Shenvi, Lars K. Beattie, Martin Wegman, Laura Melville, Richard D. Shih, Bryan Kane   +8 more
wiley   +1 more source

Pharmacokinetics and Neuroprotective Efficacy of Poly‐Arginine Peptide R18D in Sprague Dawley Rats Subjected to Transient Intraluminal Filament Middle Cerebral Artery Occlusion Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
The R18D peptide exhibits a favorable pharmacokinetic profile and significantly reduces infarct volume in a rat model of middle cerebral artery occlusion (MCAO) followed by reperfusion. These findings highlight the potential clinical utility of R18D as a neuroprotective therapy for stroke patients undergoing endovascular recanalization interventions ...
Bruno P. Meloni, Stuart K. Gribble, Meghan G. Thomas, Ayelet Weksler, Lena Finkelstein, Lena Fishtein, Dimitry Kovalchuk, Gilad Maximov, Avital Schauder, Keren Kigel‐Zur, Sigal Meilin   +10 more
wiley   +1 more source

Effect of Proximal Blood Flow Arrest During Endovascular Thrombectomy (ProFATE): a multicentre, blinded-endpoint, randomised clinical trial

BACKGROUND: The effect of temporary blood flow arrest during endovascular thrombectomy for acute ischemic stroke is uncertain due to the lack of evidence from randomized controlled trials.
Barrett, Emma, Bhogal, Pervinder, Goddard, Tony, Carraro Do Nascimento, Vinicius, Lenthall, Robert, Dhillon, Permesh Singh, McConachie, Norman, England, Timothy J, Lynch, Jeremy, Podlasek, Anna, Dineen, Robert A, Nair, Sujit, Booth, Thomas C, Jethwa, Ketan, Krishnan, Kailash, Butt, Waleed, Malik, Luqman   +16 more
core   +1 more source

A review of mechanical thrombectomy techniques for acute ischemic stroke.

, 2023
Mechanical thrombectomy is established as standard of care in the management of acute ischemic stroke due to large vessel occlusion and evidence-based guidelines for mechanical thrombectomy have been defined.
Jabbour, Pascal M, Munoz, Alfredo, Gooch, Michael Reid, El Naamani, Kareem, Al-Saiegh, Fadi, Rosenwasser, Robert H, Tjoumakaris, Stavropoula, Chen, Ching-Jen, Herial, Nabeel A, Eldin, Mohamed Shehab, Abbas, Rawad, Jabre, Roland, Orenday-Barraza, Jose M   +12 more
core  

Serum Uric Acid as a Sex‐Dependent Risk Marker of Post‐Stroke Epilepsy After Acute Ischemic Stroke: Complementary Mendelian Randomization and Cohort Analyses

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
In 21,459 acute ischemic stroke patients, Mendelian randomization found no shared genetic causal link between serum uric acid and epilepsy. Elevated admission uric acid was a robust risk marker for post‐stroke epilepsy in women but not men, with the apparent male protective association sensitive to stratification method.
Yan Cheng, Ji Li, Yunzhou Yang
wiley   +1 more source

Convulsive‐Like Movements in Posterior Circulation Large Vessel Occlusion: Associations With Midbrain Injury and Poor Outcome

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Graphical abstract illustrating the association between convulsive‐like movements, midbrain injury, and unfavorable 90‐day functional outcome in posterior circulation large vessel occlusion (LVO). ABSTRACT Background and Purpose Convulsive‐like movements are an uncommon and frequently misinterpreted manifestation of posterior circulation stroke ...
Wan Wang, Juntao Yin, Boyi Yuan, Zixin Wang, Jiamin Li, Yun Chen, Jiameng Li, Xinyi Wang, Jiapeng Zhao, Jinming Sheng, Qingfeng Ma   +10 more
wiley   +1 more source

Efficacy of Intravenous Tenecteplase Bridge Thrombectomy for Recurrent Ischemic Stroke Within 3 Months: A Case Report

Cuicui Liu, Junyan Liu, Huiling Ren, Yuzhu Xu, Wanhu Liu Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of ChinaCorrespondence: Wanhu Liu, Department of Neurology, The Third Hospital of Hebei ...
Ren H, Liu J, Liu C, Xu Y, Liu W
core  

Treatment of portal vein thrombosis by thrombectomy and regional thrombolysis

, 1994
BACKGROUND. Portal vein thrombosis is a rare disorder. The prognosis of both the acute and the chronic forms is determined by the resulting acute or chronic portal hypertension. The therapeutic approach of choice is controversial. METHODS.
Gulba, D., Rosenthal, H., Demertzis, S, Ringe, B, Rosenthal, H, Demertzis, S., Gulba, D, Pichlmayr, R, Pichlmayr, R., Ringe, B.   +9 more
core