Results 31 to 40 of about 5,734 (191)

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Efficacy and Safety of Intravenous Tenecteplase Before Endovascular Thrombectomy for Acute Ischemic Stroke: The Multicenter, Randomized, BRIDGE‐TNK Trial Protocol

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and endovascular thrombectomy alone in stroke.
Zhongming Qiu, Fengli Li, Dongjing Xie, Guangxiong Yuan, Thanh N. Nguyen, Kai Zhou, Raul G. Nogueira, Jeffrey L. Saver, Bruce C.V. Campbell, Gregory W. Albers, Hongfei Sang, Linyu Li, Yan Tian, Zhaoyou Meng, Duolao Wang, Wenjie Zi, Qingwu Yang   +16 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

How a thrombectomy service can reduce hospital deficit: a cost-effectiveness study

Cost Effectiveness and Resource Allocation, 2022
Background There is level 1 evidence for cerebral thrombectomy with thrombolysis in acute large vessel occlusion. Many hospitals are now contemplating setting up this life-saving service.
Iris Q. Grunwald, Viola Wagner, Anna Podlasek, Gouri Koduri, Paul Guyler, Stephen Gerry, Sweni Shah, Horst Sievert, Aarti Sharma, Shrey Mathur, Klaus Fassbender, Kaveh Shariat, Graeme Houston, Avinash Kanodia, Silke Walter   +14 more
doaj   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Thrombectomy Use in the United States for Basilar Artery Occlusion in the Era of Neutral Clinical Trials: 2018 to 2020 Analysis of the National Inpatient Sample

Stroke: Vascular and Interventional Neurology
Background In 2019 and 2020, 2 randomized trials of basilar artery occlusion (BAO) thrombectomy reported no improvement in functional outcomes with thrombectomy, despite observational evidence.
James E. Siegler, Karan Patel, Kamil Taneja, Matthew B. Obusan, Manisha Koneru, Shadi Yaghi, Fawaz Al‐Mufti, Tareq Kass‐Hout, Thanh N. Nguyen   +8 more
doaj   +1 more source

Abstract 218: Evaluating Thrombectomy Candidacy in Large Core Strokes: Lessons from the SELECT2 Trial at Our Institution

Stroke: Vascular and Interventional Neurology, 2023
Introduction Reperfusion therapy for patients with large vessel occlusion stroke includes thrombolytics and mechanical thrombectomy. Candidacy for thrombectomy depends on patient factors under active investigation.
Mohammad Khasawneh, Eve Moll, Brendan Eby, Laura Heitsch   +3 more
doaj   +1 more source

Direct to Thrombectomy [PDF]

Stroke, 2021
Kyriakos Lobotesis, Brian H. Buck
openaire   +2 more sources

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source