Results 131 to 140 of about 20,052 (177)

Essential Thrombocythemia in Childhood

Seminars in Thrombosis and Hemostasis, 1997
In addition to the criteria of the Polycythemia Vera Study Group, positive markers for essential thrombocythemia (ET) include spontaneous BFU-E, splenomegaly, and megakaryocyte morphology in bone marrow smears and biopsy material. The hematologic features of 11 reported cases of ET in childhood showed platelet counts in excess of 1000 x 10(9)/L in all,
J J, Michiels, P J, Van Genderen
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Essential Thrombocythemia

JAMA
ImportanceEssential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. The annual incidence rate of essential thrombocythemia in the US is 1.5/100 000 persons.ObservationsPatients with essential thrombocythemia have a persistent platelet count of 450 
Ayalew, Tefferi, Naseema, Gangat, Giuseppe Gaetano, Loscocco, Paola, Guglielmelli, Natasha, Szuber, Animesh, Pardanani, Attilio, Orazi, Tiziano, Barbui, Alessandro Maria, Vannucchi   +8 more
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Essential Thrombocythemia and Pregnancy

Leukemia & Lymphoma, 1996
A review of the literature disclosed 106 pregnancies (preg.) in 57 women with essential thrombocythemia (ET). The success rate (baby alive) was 57% (60 live births/106 preg.), the rate of miscarriage 43% (46 miscarriages/106 preg.). The most frequent complication was spontaneous abortion during the first trimester in 36% (38 abortions/106 preg.). Other
M, Griesshammer, H, Heimpel, T C, Pearson   +2 more
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Essential Thrombocythemia in an Infant

Journal of Pediatric Hematology/Oncology, 1996
To report the unusual occurrence of essential thrombocythemia (ET) in a 5-month-old infant.The child was referred by her pediatrician for a high platelet count detected on routine blood testing. The child was asymptomatic except for failure to thrive. Diagnostic tests to rule out secondary causes of thrombocytosis as well as myeloproliferative syndrome
G, Kapoor, H, Correa, L C, Yu
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Essential thrombocythemia and pregnancy

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2011
Essential thrombocythaemia (ET) is an acquired myeloproliferative neoplasm, characterised by persistent thrombocytosis and a tendency for either thrombosis or haemorrhage. Among myeloproliferative neoplasms, ET is the most prevalent in young women, which constitute a special group due to their childbearing potential.
Valera, Marie-Cécile, Parant, Olivier, Vayssiere, Christophe, Arnal, Jean-François, Payrastre, Bernard   +4 more
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Pharmacotherapy of essential thrombocythemia

Expert Opinion on Pharmacotherapy, 2008
The natural history of essential thrombocythemia is characterized by an increased incidence of thrombotic and hemorrhagic events and, in the long-term, a tendency for disease transformation to myelofibrosis or acute leukemia. Advanced age and a prior history of thrombosis are the major predictors of thrombotic complications.The aim of this study was to
Naseema, Gangat, Ayalew, Tefferi
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Familial essential thrombocythemia

The American Journal of Medicine, 1986
Primary or essential thrombocythemia is rarely observed in childhood, and familial occurrence has been reported only once. In this study, essential thrombocythemia is documented in five members of both sexes from two to 62 years of age in three successive generations.
M E, Eyster, S L, Saletan, E M, Rabellino, A, Karanas, T P, McDonald, L A, Locke, J R, Luderer   +6 more
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Essential Thrombocythemia in Children

Journal of Pediatric Hematology/Oncology, 1999
The objective of this study was to evaluate the clinical course, laboratory findings, and outcomes of children with essential thrombocythemia (ET).The authors analyzed 36 children, ages 6 weeks to 18 years, by combining descriptions of 2 patients observed at their institution with 34 patients reported in the English medical literature.Fifteen patients (
Y, Dror, A, Zipursky, V S, Blanchette
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The pathogenesis of essential thrombocythemia

Current Opinion in Hematology, 2011
The identification of new mutations continues to further our understanding of the molecular pathogenesis of essential thrombocythemia and related disorders, and offers opportunities for improvements in diagnosis, risk stratification and disease classification.Molecular lesions in essential thrombocythemia affect two distinct pathways: cytokine ...
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Management of Essential Thrombocythemia

Hematology, 2011
Abstract Essential thrombocythemia (ET) is a Philadelphia chromosome (Ph)–negative myeloproliferative neoplasm (MPN) characterized by thrombocytosis and megakaryocytic hyperplasia of the bone marrow, with presence of the JAK2 V617F mutation in 50%-60% of patients. ET evolves to myelofibrosis in a minority of cases, whereas transformation
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