Primary myelofibrosis shows histological and pathogenetic overlap with essential thrombocythemia and polycythemia vera. Several diagnostic classifications have been proposed for primary myelofibrosis, although little is known about their clinical utility.
Philip A. Beer +2 more
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Background Most cell types, including blood - and vascular cells, produce microparticles upon activation. Since cellular microparticles are known to be elevated in thromboembolic diseases, we hypothesized a role for microparticles in the pathogenesis of ...
Marijke C. Trappenburg +7 more
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Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms
Somatic mutations of MPL exon 10, mainly involving a W515 substitution, have been described in JAK2 (V617F)-negative patients with essential thrombocythemia and primary myelofibrosis.
Daniela Pietra +11 more
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BCR/ABL positive thrombocythemia: a diagnostic dilemma
Both chronic myeloid leukemia and essential thrombocythemia are part of the spectrum of myeloproliferative neoplasm. Therefore, considerable overlap may occur in the clinical manifestations, and hematological and molecular findings in some patients.
Lubna Zafar +3 more
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Giona F, Teofili L, Capodimonti S, et al. CALR mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence. Blood. 2014;123(23):3677-3679. [PDF]
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Novel European Asiatic Clinical, Laboratory, Molecular and Pathobiological (2015-2020 CLMP) criteria for JAK2V617F trilinear polycythemia vera (PV), JAK2exon12 PV and JAK2V617F, CALR and MPL515 thrombocythemias: From Dameshek to Constantinescu-Vainchenker, Kralovics and Michiels [PDF]
Michiels Jan Jacques +12 more
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Heparin-Induced Thrombocytopenia in a Patient with Essential Thrombocythemia: A Case Based Update [PDF]
Edva Noel +3 more
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JAK2V617F monitoring in polycythemia vera and essential thrombocythemia: Clinical usefulness for predicting myelofibrotic transformation and thrombotic events [PDF]
Alberto Álvarez‐Larrán +15 more
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Complex intracranial vascular complications caused by essential thrombocythemia: a critical case report [PDF]
Jian Xie +4 more
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[How I diagnose and treat essential thrombocythemia]. [PDF]
L Zhang, Rongfeng Fu
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