Results 91 to 100 of about 432,090 (383)

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know

open access: yesBlood, 2021
Development of vaccines to fight COVID19has been a remarkable medical achievement. However, this global immunization effort has been complicated by arare vaccine-related outcome characterized by thrombocytopenia and thrombosisin association with ...
G. Arepally, T. Ortel
semanticscholar   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

open access: yesAdvanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun   +23 more
wiley   +1 more source

Impact of Thrombocytopenia on In-Hospital Outcome in Patients Undergoing Percutaneous Coronary Intervention

open access: yesCardiovascular Therapeutics, 2021
Background. Thrombocytopenia was intuitively considered to be associated with higher risk of bleeding and multiple comorbidities after percutaneous coronary intervention (PCI).
Zhongxiu Chen   +9 more
doaj   +1 more source

Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non–Small Cell Lung Cancer: A Phase Ib Study [PDF]

open access: yes, 2018
Purpose: Abemaciclib, a dual inhibitor of cyclin-dependent kinases 4 and 6, has demonstrated preclinical activity in non–small cell lung cancer (NSCLC).
Beckmann, Richard   +16 more
core   +1 more source

Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP)

open access: yesJournal of Clinical Medicine, 2017
Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated and/or T cell-mediated platelet destruction are key processes.
A. Zufferey, R. Kapur, J. Semple
semanticscholar   +1 more source

Severe Fever with Thrombocytopenia Syndrome, Japan, 2013–2017

open access: yesEmerging Infectious Diseases, 2020
We conducted an epidemiologic study of severe fever with thrombocytopenia syndrome (SFTS) in Japan during 2013–2017. Of 303 cases reported during that period, 133 (44%) were included in this study.
Yusuke Kobayashi   +11 more
semanticscholar   +1 more source

Clinical and immunological characterisation of patients with common variable immunodeficiency related immune thrombocytopenia [PDF]

open access: hybrid, 2023
N. P. Somasundaram   +6 more
openalex   +1 more source

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

open access: yesAdvanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour   +14 more
wiley   +1 more source

Prevalence and aetiology of moderate and severe thrombocytopenia in a tertiary and quaternary centre in KwaZulu-Natal

open access: yesAfrican Journal of Laboratory Medicine, 2020
Background: Thrombocytopenia is a common haematological disorder, characterised by platelet counts below 150 × 109/L. The aetiology of thrombocytopenia is multifactorial; notably, in a misdiagnosis this condition may be due to pre-analytical laboratory ...
Ayanda G. Jali, Bongani B. Nkambule
doaj   +1 more source

Thrombotic Thrombocytopenic Purpura, Moschcowitz Syndrome [PDF]

open access: yes, 2001
The authors present a case of a 16-year-old boy, who was referred to the hospital due to thrombocytopenia, anemia, proteinuria and hyperbilirubinemia. Based on the clinical picture and the laboratory data, thrombotic thrombocytopenic purpura (TTP) was ...
Czinyéri, Judit   +4 more
core  

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