Results 91 to 100 of about 288,284 (303)

Thrombocytopenia in Dengue Hemorrhagic Fever

open access: yesPaediatrica Indonesiana, 2019
According to WHO thrombocytopenia is one of the diagnostic criteria of DHF. On the other hand many studies have reported DHF cases without evidence of thrombocytopenia.
Sunarto Sunarto, Sutaryo Sutaryo
doaj   +1 more source

Bleeding in neonates with severe thrombocytopenia: a retrospective cohort study

open access: yesBMC Pediatrics, 2022
Background Severe neonatal thrombocytopenia is a rare disease with multiple etiologies. Severe thrombocytopenia with bleeding is life-threatening and has attracted significant attention from clinicians.
Ting Peng   +3 more
doaj   +1 more source

Correlation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study

open access: yesAdvanced Science, EarlyView.
This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu   +38 more
wiley   +1 more source

International consensus report on the investigation and management of primary immune thrombocytopenia.

open access: yesBlood, 2010
Previously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysiology ...
D. Provan   +21 more
semanticscholar   +1 more source

Association between thrombocytopenia and 180-day prognosis of COVID-19 patients in intensive care units: A two-center observational study

open access: yesPLoS ONE, 2021
Background Thrombocytopenia has been proved to be associated with hospital mortality in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.
Yuanfang Zhu   +5 more
semanticscholar   +1 more source

Whole-genome sequence of Macaca fascicularis: liver tissue

open access: yesBMC Genomic Data, 2023
Objectives Thrombocytopenia is a condition that causes a low amount of blood platelets. Platelets are blood cells that play an essential role in blood coagulation.
Eun-Hye Seo   +4 more
doaj   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

open access: yesAdvanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu   +10 more
wiley   +1 more source

Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling

open access: yesAdvanced Science, EarlyView.
This research presents a novel strategy employing the VGM cocktail, which combines HES7 overexpression with HDAC inhibitor and GABA, to enhance platelet production from hematopoietic stem and progenitor cells by promoting megakaryocyte progenitor (MkP) generation.
Huicong Liu   +6 more
wiley   +1 more source

Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study

open access: yesHepatology, EarlyView., 2022
Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel   +93 more
wiley   +1 more source

Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures [PDF]

open access: yesarXiv, 2020
Temporal inference from laboratory testing results and their triangulation with clinical outcomes as described in the associated unstructured text from the providers notes in the Electronic Health Record (EHR) is integral to advancing precision medicine. Here, we studied 181 COVIDpos and 7,775 COVIDneg patients subjected to 1.3 million laboratory tests
arxiv  

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