Results 121 to 130 of about 213,347 (314)

Amegakaryocytic Thrombocytopenia

, 2021
Amegakaryocytic thrombocytopenia is a severe form of thrombocytopenia with reduced or absent megakaryocytes in the bone marrow. It can be congenital or acquired.
De Jesus, Orlando, Said, Mina, Tirthani, Ekta   +2 more
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Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

British Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić, Elvira Meni Maria Gkrinia, Patrick Eustaquio, Andrea Katrin Faour, Dinko Vitezić   +4 more
wiley   +1 more source

Inflammation induces hemorrhage in thrombocytopenia

, 2008
The role of platelets in hemostasis is to produce a plug to arrest bleeding. During thrombocytopenia, spontaneous bleeding is seen in some patients but not in others; the reason for this is unknown.
Cifuni, Stephen M, Wagner, Denisa D, Goerge, Tobias, Remold-O'Donnell, Eileen, Zhao, Bing-Qiao, Benarafa, Charaf, Ho-Tin-Noe, Benoit, Carbo, Carla   +7 more
core   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance

Clinical and Applied Thrombosis/Hemostasis, 2019
Thrombocytopenia (less than 100 × 10 9 /L platelets) presents in around one quarter of patients with nonalcoholic fatty liver disease (NAFLD), the hepatic component of insulin resistance (IR).
Miguel Antonio López-Trujillo Bsc, Jesús Mauricio Olivares-Gazca MD, Yahveth Cantero-Fortiz MD, Yarely Itzayana García-Navarrete MD, Antonio Cruz-Mora MD, Juan Carlos Olivares-Gazca MD, Iván Murrieta-Álvarez MD, Andrés Aurelio León-Peña MD, Guillermo J. Ruiz-Delgado MD, FACP, Guillermo J. Ruiz-Argüelles MD, FACP FRCP (Glasg), MACP, DSc (hon)   +9 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Prevalence of thrombocytopenia among pregnant women attending antenatal care service at Gondar University Teaching Hospital in 2014, northwest Ethiopia

, 2017
Fikir Asrie, Bamlaku Enawgaw, Zegeye Getaneh Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Introduction ...
Getaneh Z, Asrie F, Enawgaw B
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Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Risk factors for thrombocytopenia associated with intravenous valproic acid therapy in pediatric patients undergoing neurosurgical operations

Scientific Reports
Thrombocytopenia is one of the side effects of VPA. This study aimed to evaluate the incidence and risk factors of thrombocytopenia after intravenous VPA treatment in children with neurosurgical operations.
Zhaosong Du, Jun Wang, Gang Nie, Ying Li, Maochang Liu   +4 more
doaj   +1 more source

Immune thrombocytopenia: improving quality of life and patient outcomes

, 2018
Patrick Trotter,1,2 Quentin A Hill3 1Department of Surgery, University of Cambridge, Cambridge, UK; 2National Health Service Blood and Transplant, Organ Donation and Transplant Directorate, Bristol, UK; 3Department of Haematology, St James’s ...
Trotter P, Hill QA
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